中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
8期
20-22
,共3页
帕金森病%非运动症状%睡眠障碍
帕金森病%非運動癥狀%睡眠障礙
파금삼병%비운동증상%수면장애
Parkinson’s disease%Non-motor symptoms%Sleep disorder
目的：探讨帕金森病（PD）非运动症状（NMS）的发病情况及其在评估帕金森病严重程度中的作用。方法选择我院2010‐10—2014‐06门诊及住院210例PD患者为观察组；选取同期门诊就诊的非PD患者180例为对照组。采用帕金森病非运动症状筛查量表对2组的NMS发病情况进行调查，分析PD患者的NMS临床特征及其在评估帕金森病严重程度中的作用。结果观察组NMS发生总数为1～23项，平均（11.7±5.3）项，显著高于对照组（P＜0.01）；各项NMS发生率比较，观察组显著高于对照组（P＜0.01）。分析显示，PD患者NMS发生项数与病程和病情严重程度具有相关性（P＜0.05）。结论自主神经功能障碍、睡眠障碍、焦虑、抑郁是PD 患者最常见的非运动症状，NMS 发生总数与PD 患者病程及病情严重程度相关，可以作为评价PD 严重程度和进展的一项指标。
目的：探討帕金森病（PD）非運動癥狀（NMS）的髮病情況及其在評估帕金森病嚴重程度中的作用。方法選擇我院2010‐10—2014‐06門診及住院210例PD患者為觀察組；選取同期門診就診的非PD患者180例為對照組。採用帕金森病非運動癥狀篩查量錶對2組的NMS髮病情況進行調查，分析PD患者的NMS臨床特徵及其在評估帕金森病嚴重程度中的作用。結果觀察組NMS髮生總數為1～23項，平均（11.7±5.3）項，顯著高于對照組（P＜0.01）；各項NMS髮生率比較，觀察組顯著高于對照組（P＜0.01）。分析顯示，PD患者NMS髮生項數與病程和病情嚴重程度具有相關性（P＜0.05）。結論自主神經功能障礙、睡眠障礙、焦慮、抑鬱是PD 患者最常見的非運動癥狀，NMS 髮生總數與PD 患者病程及病情嚴重程度相關，可以作為評價PD 嚴重程度和進展的一項指標。
목적：탐토파금삼병（PD）비운동증상（NMS）적발병정황급기재평고파금삼병엄중정도중적작용。방법선택아원2010‐10—2014‐06문진급주원210례PD환자위관찰조；선취동기문진취진적비PD환자180례위대조조。채용파금삼병비운동증상사사량표대2조적NMS발병정황진행조사，분석PD환자적NMS림상특정급기재평고파금삼병엄중정도중적작용。결과관찰조NMS발생총수위1～23항，평균（11.7±5.3）항，현저고우대조조（P＜0.01）；각항NMS발생솔비교，관찰조현저고우대조조（P＜0.01）。분석현시，PD환자NMS발생항수여병정화병정엄중정도구유상관성（P＜0.05）。결론자주신경공능장애、수면장애、초필、억욱시PD 환자최상견적비운동증상，NMS 발생총수여PD 환자병정급병정엄중정도상관，가이작위평개PD 엄중정도화진전적일항지표。
Objective To explore the role of non‐motor symptoms(NMS) in evaluating disease severity and progression of Parkinson’s disease (PD) .Methods 210 patients with Parkinson disease treated in our hospital from October 2010 to June 2014 were selected as the observation group;180 out‐patients without PD at the same period were selected as the control group;the Non‐Motor Symptom Questionnaire was used to survey the prevalence of NMS in two groups ,the clinical characteristics of NMS were analyzed and its role in severity evaluation of PD was assessed .Results the total number of NMS in patients of the observation group ranged from 1 to 23 ,mean(11 .7 ± 5 .3) ,which was significantly higher than that of the control group . There were 18 items of NMS in the observation group ,the incidence rate of which was higher than that of the control group(P<0 .01 or P<0 .05) .The analysis showed that the total number of NMS occurred in patients was closely correlated with the course and the severity of PD(P<0 .05) .Conclusion Autonomic nervous dysfunction ,sleep disorder ,anxiety and depression are the most common non‐motor symptoms ,the total number of NMS was related to the course and the severity of PD ,which may be regarded as an index to evaluate disease severity and progression of Parkinson’s disease (PD) .
