中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
2期
312-314
,共3页
妊娠期肝内胆汁淤积症%早产%羊水污染%早发型%围产儿
妊娠期肝內膽汁淤積癥%早產%羊水汙染%早髮型%圍產兒
임신기간내담즙어적증%조산%양수오염%조발형%위산인
intrahepatic cholestasis of pregnancy( ICP)%preterm birth%amniotic fluid contamination%early onset%perinates
目的：探讨不同发病时间的妊娠期肝内胆汁淤积症（ ICP）围产儿的不良结局。方法收集在成都大学附属医院住院分娩的ICP病例，并回顾性分析522例ICP病例的产科因素与围产儿不良结局之间的关系。结果按发病时间不同将ICP围产儿分成3组，并与早产、出生窒息、羊水污染和小于胎龄儿4种不良结局发病率比较，差异均有统计学意义（χ2值分别为111．516、36．110、22．368、24．519，均P＜0．05）。卡方分割得出≤32w发病组在早产、出生窒息、羊水污染的发生率均高于另两组（χ2值分别为71．824、36．011、32．178，均P＜0．05），32＋1～34w发病组的早产和小于胎龄儿发生率高于＞34w发病组（χ2值分别为46．652、21．856，均P＜0．05）。结论 ICP围产儿的早产发生率随发病时间提前而升高，以32w发病来定义早发型ICP可能比34w更合适。
目的：探討不同髮病時間的妊娠期肝內膽汁淤積癥（ ICP）圍產兒的不良結跼。方法收集在成都大學附屬醫院住院分娩的ICP病例，併迴顧性分析522例ICP病例的產科因素與圍產兒不良結跼之間的關繫。結果按髮病時間不同將ICP圍產兒分成3組，併與早產、齣生窒息、羊水汙染和小于胎齡兒4種不良結跼髮病率比較，差異均有統計學意義（χ2值分彆為111．516、36．110、22．368、24．519，均P＜0．05）。卡方分割得齣≤32w髮病組在早產、齣生窒息、羊水汙染的髮生率均高于另兩組（χ2值分彆為71．824、36．011、32．178，均P＜0．05），32＋1～34w髮病組的早產和小于胎齡兒髮生率高于＞34w髮病組（χ2值分彆為46．652、21．856，均P＜0．05）。結論 ICP圍產兒的早產髮生率隨髮病時間提前而升高，以32w髮病來定義早髮型ICP可能比34w更閤適。
목적：탐토불동발병시간적임신기간내담즙어적증（ ICP）위산인적불량결국。방법수집재성도대학부속의원주원분면적ICP병례，병회고성분석522례ICP병례적산과인소여위산인불량결국지간적관계。결과안발병시간불동장ICP위산인분성3조，병여조산、출생질식、양수오염화소우태령인4충불량결국발병솔비교，차이균유통계학의의（χ2치분별위111．516、36．110、22．368、24．519，균P＜0．05）。잡방분할득출≤32w발병조재조산、출생질식、양수오염적발생솔균고우령량조（χ2치분별위71．824、36．011、32．178，균P＜0．05），32＋1～34w발병조적조산화소우태령인발생솔고우＞34w발병조（χ2치분별위46．652、21．856，균P＜0．05）。결론 ICP위산인적조산발생솔수발병시간제전이승고，이32w발병래정의조발형ICP가능비34w경합괄。
Objective To explore the adverse outcomes of neonates with intrahepatic cholestasis at pregnancy (ICP) at different onset time.Methods The ICP cases were collected in Affiliated Hospital of Chengdu University.Totally 522 cases of ICP were analyzed retrospectively to discuss the relationship between obstetric factors and adverse perinatal outcomes.Results The incidence of perinatal adverse outcomes including premature delivery, birth asphyxia, amniotic fluid contamination and small for gestational age was compared with the onset time of three groups, and the differences were significant (χ2 value was 111.516, 36.110, 22.368 and 24.519, respectively, all P<0.05).The incidence of preterm birth, birth asphyxia and amniotic fluid contamination was higher in ≤32w onset group then in other two groups (χ2 value was 71.824, 36.011 and 32.178, respectively, all P<0.05).Compared with >34w onset group, the incidence of preterm birth and small for gestational age was higher in 32 +1 -34w onset group (χ2 value was 46.652 and 21.856, respectively, both P<0.05) .Conclusion The incidence of preterm birth increases when the onset is advanced.Defining early-onset ICP with 32w onset is more appropriate than 34w.
