大众科技
大衆科技
대음과기
DAZHONG KEJI
2015年
3期
108-110
,共3页
苯并咪唑衍生物%抗菌%最小抑菌浓度
苯併咪唑衍生物%抗菌%最小抑菌濃度
분병미서연생물%항균%최소억균농도
Benzimidazole derivatives%antibacterial%minimum inhibitory concentration
以15种苯并咪唑衍生物为抑菌实验测试药品，以大肠杆菌、金色葡萄糖球菌等10种细菌作为受试菌种，通过平板法定性测定样品的抗菌活性。结果表明，除丁二苯并咪唑外，其他的化合物都表现出一定的抑菌活性。同时通过试管法定量测定了样品的最小抑菌浓度(MIC)，实验结果表明，化合物对细菌都有较好的抑菌活性，其中2-(2-(1H-benzo[d]imidazol-2-yl) pyridin-3-yl)-1H-benzo[d]imidazole、2,3-吡啶二羧酸、1,2-di(1H-benzo [d]imidazol-2-yl) ethane-1,2-diol、2-phenyl-1H-benzo[d] imidazole具有广谱的抑菌活性，2,2’-联咪唑对枯草杆菌的MIC为0.8μg/mL,2,3-吡啶二羧酸对肺炎球菌的MIC为1.0μg/mL。
以15種苯併咪唑衍生物為抑菌實驗測試藥品，以大腸桿菌、金色葡萄糖毬菌等10種細菌作為受試菌種，通過平闆法定性測定樣品的抗菌活性。結果錶明，除丁二苯併咪唑外，其他的化閤物都錶現齣一定的抑菌活性。同時通過試管法定量測定瞭樣品的最小抑菌濃度(MIC)，實驗結果錶明，化閤物對細菌都有較好的抑菌活性，其中2-(2-(1H-benzo[d]imidazol-2-yl) pyridin-3-yl)-1H-benzo[d]imidazole、2,3-吡啶二羧痠、1,2-di(1H-benzo [d]imidazol-2-yl) ethane-1,2-diol、2-phenyl-1H-benzo[d] imidazole具有廣譜的抑菌活性，2,2’-聯咪唑對枯草桿菌的MIC為0.8μg/mL,2,3-吡啶二羧痠對肺炎毬菌的MIC為1.0μg/mL。
이15충분병미서연생물위억균실험측시약품，이대장간균、금색포도당구균등10충세균작위수시균충，통과평판법정성측정양품적항균활성。결과표명，제정이분병미서외，기타적화합물도표현출일정적억균활성。동시통과시관법정량측정료양품적최소억균농도(MIC)，실험결과표명，화합물대세균도유교호적억균활성，기중2-(2-(1H-benzo[d]imidazol-2-yl) pyridin-3-yl)-1H-benzo[d]imidazole、2,3-필정이최산、1,2-di(1H-benzo [d]imidazol-2-yl) ethane-1,2-diol、2-phenyl-1H-benzo[d] imidazole구유엄보적억균활성，2,2’-련미서대고초간균적MIC위0.8μg/mL,2,3-필정이최산대폐염구균적MIC위1.0μg/mL。
15 kinds of benzimidazole derivatives as antibacterial drug testing experiments, E. coli, and other 10 kinds of golden glucose cocci bacteria as bacteria tested by the statutory determination of the sample flat antibacterial activity. The results show that, in addition to succinic benzimidazole, other compounds have shown some antibacterial activity. Meanwhile through in vitro quantitative determination of the minimum inhibitory concentration of the sample (MIC), the experimental results show that the compounds of the bacteria have good antibacterial activity, including 2-(2-(1H-benzo [d] imidazol-2-yl) pyridin-3-yl)-1H-benzo [d] imidazole, 2,3-pyridinedicarboxylic acid, 1,2-di (1H-benzo [d] imidazol-2-yl) ethane-1,2- diol, 2-phenyl-1H-benzo [d] imidazole has a broad spectrum of antibacterial activity against Bacillus subtilis 2,2'-imidazole MIC was 0.8μg/mL, 2,3-dicarboxylic acid pyridine pneumococcal the MIC was 1.0μg/mL.
