中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
11期
43-45
,共3页
负压封闭引流%糖尿病足%肉芽组织%PDGFR%表达%影响
負壓封閉引流%糖尿病足%肉芽組織%PDGFR%錶達%影響
부압봉폐인류%당뇨병족%육아조직%PDGFR%표체%영향
Vacuum sealing drainage%Diabetic foot%Granulation tissue%PDGFR%Expression%Influence
目的：探讨负压封闭引流(VSD)技术对糖尿病足肉芽组织PDGFR表达的影响及其临床意义。方法选择2010年1月~2014年2月在本院住院的糖尿病足2~3级的患者60例。将患者随机分成负压组和对照组，每组30例。负压组患者采用VSD技术治疗，对照组患者采用常规湿性换药的方法治疗。两组患者进行肉芽组织活检并比较两组的PDGFR含量。结果正常皮肤组织、溃疡边缘组织、溃疡组织中的血小板源性生长因子(PDGF)含量差异无统计学意义(P>0.05)，但溃疡组织中的PDGFR含量明显降低(P<0.05)。两组治疗前的PDGF亚基及PDGFR亚型含量差异无统计学意义(P>0.05)；两组治疗后的PDGFR-α、PDGFR-β含量与治疗前比较，差异有统计学意义(P<0.05)；负压组治疗后的PDGFR-α、PDGFR-β含量与对照组比较，差异有统计学意义(P<0.05)。结论VSD技术能增加局部皮肤的血液循环，增加PDGFR含量，刺激成纤维细胞增生，具有一定的推广应用价值。
目的：探討負壓封閉引流(VSD)技術對糖尿病足肉芽組織PDGFR錶達的影響及其臨床意義。方法選擇2010年1月~2014年2月在本院住院的糖尿病足2~3級的患者60例。將患者隨機分成負壓組和對照組，每組30例。負壓組患者採用VSD技術治療，對照組患者採用常規濕性換藥的方法治療。兩組患者進行肉芽組織活檢併比較兩組的PDGFR含量。結果正常皮膚組織、潰瘍邊緣組織、潰瘍組織中的血小闆源性生長因子(PDGF)含量差異無統計學意義(P>0.05)，但潰瘍組織中的PDGFR含量明顯降低(P<0.05)。兩組治療前的PDGF亞基及PDGFR亞型含量差異無統計學意義(P>0.05)；兩組治療後的PDGFR-α、PDGFR-β含量與治療前比較，差異有統計學意義(P<0.05)；負壓組治療後的PDGFR-α、PDGFR-β含量與對照組比較，差異有統計學意義(P<0.05)。結論VSD技術能增加跼部皮膚的血液循環，增加PDGFR含量，刺激成纖維細胞增生，具有一定的推廣應用價值。
목적：탐토부압봉폐인류(VSD)기술대당뇨병족육아조직PDGFR표체적영향급기림상의의。방법선택2010년1월~2014년2월재본원주원적당뇨병족2~3급적환자60례。장환자수궤분성부압조화대조조，매조30례。부압조환자채용VSD기술치료，대조조환자채용상규습성환약적방법치료。량조환자진행육아조직활검병비교량조적PDGFR함량。결과정상피부조직、궤양변연조직、궤양조직중적혈소판원성생장인자(PDGF)함량차이무통계학의의(P>0.05)，단궤양조직중적PDGFR함량명현강저(P<0.05)。량조치료전적PDGF아기급PDGFR아형함량차이무통계학의의(P>0.05)；량조치료후적PDGFR-α、PDGFR-β함량여치료전비교，차이유통계학의의(P<0.05)；부압조치료후적PDGFR-α、PDGFR-β함량여대조조비교，차이유통계학의의(P<0.05)。결론VSD기술능증가국부피부적혈액순배，증가PDGFR함량，자격성섬유세포증생，구유일정적추엄응용개치。
Objective To investigate the influence of vacuum sealing drainage (VSD) on PDGFR expression of granula-tion tissue for diabetic foot and its clinical significance. Methods 60 patients with diabetic foot of class 2-3 treated in our hospital from January 2010 to February 2014 were selected and they were randomly divided into negative pressure group (n=30) and control group (n=30).Negative pressure group was treated with VSD technology,while control group was treated with conventional wet dressing.Patients of two groups were given granulation tissue biopsy and PDGFR content between two groups was compared. Results There was no statistical difference of platelet derived growth factor (PDGF) content among the normal skin tissue,the ulcer margin tissue and ulcer tissue (P>0.05),but PDGFR content of ulcer tissue was obviously decreased (P<0.05).There was no statistical difference of PDGF subunit and PDGFR subtype content before treatment between two groups (P>0.05),and there was a statistical difference of PDGFR-α and PDGFR-βcontent after treatment compared with before treatment (P<0.05),and there was a statistical difference of PDGFR-αand PDGFR-βcontent after treatment in negative pressure group compared with control group (P<0.05). Conclusion VSD technology can increase the blood circulation of local skin,increase the PDGFR content,and stimulate the proliferation of fibroblast.It has certain promotion and application value.
