CAJ | 학술논문

目的：探讨多巴胺与去甲肾上腺素在休克治疗中的应用；方法：选择休克患者共200例，按照治疗方法，分为多巴胺组（DA组）（n＝65），去甲肾上腺素组（NE组）（n＝65），多巴胺联合去甲肾上腺素组（ DA＋NE组）（ n＝70），比较治疗效果与并发症的发生率，并比较各组28d的死亡率。结果：治疗后血肌酐水平在三组中有显著差异，DA组血肌酐水平显著高于NE组和DA＋NE组，其他各项无统计学差异。 DA组治疗期间心律失常的发生率为30．76％，显著高于NE组的13．85％（χ2＝5．370，P＝0．021），DA＋NE组为20．0％。 DA组28d死亡率为24．62％，NE组死亡率为21．54％，DA＋NE组为18．57％，三者无统计学差异（χ2＝0．725，P＝0．394）。结论：去甲肾上腺素在休克的治疗中，在稳定心率以及降低对肾功能损伤等方面较多巴胺具有更明显的优势，是目前治疗休克最佳药物。
목적：탐토다파알여거갑신상선소재휴극치료중적응용；방법：선택휴극환자공200례，안조치료방법，분위다파알조（DA조）（n＝65），거갑신상선소조（NE조）（n＝65），다파알연합거갑신상선소조（ DA＋NE조）（ n＝70），비교치료효과여병발증적발생솔，병비교각조28d적사망솔。결과：치료후혈기항수평재삼조중유현저차이，DA조혈기항수평현저고우NE조화DA＋NE조，기타각항무통계학차이。 DA조치료기간심률실상적발생솔위30．76％，현저고우NE조적13．85％（χ2＝5．370，P＝0．021），DA＋NE조위20．0％。 DA조28d사망솔위24．62％，NE조사망솔위21．54％，DA＋NE조위18．57％，삼자무통계학차이（χ2＝0．725，P＝0．394）。결론：거갑신상선소재휴극적치료중，재은정심솔이급강저대신공능손상등방면교다파알구유경명현적우세，시목전치료휴극최가약물。
Objective:To investigate dopamine and norepinephrine in shock therapy.Method:A total of 200 shock patients were collected.According to the method of treatment, they were divided into dopamine ( DA) group ( n =65) , norepinephrine ( NE) group ( n =65) , dopamine and norepinephrine ( DA+NE) group (n =70).Treatment efficacy, incidence of complications and 28 days mortality were compared be-tween groups.Result: After treatment, serum creatinine levels in three groups were significantly different. Serum creatinine levels in DA group were significantly higher than the NE group and DA +NE group.Other indicators had no statistical difference.Arrhythmia was 30.76%in the DA group, which was significantly higher than 13.85%in the NE group (χ2=5.370, P =0.021) , and DA +NE group was 20.0%.28 days mortality rate in DA group was 24.62%, but in NE group, the mortality rate was 21.54%, and DA +NE group was 18.57%.There was no significant difference the three (χ2=0.725;P =0.394) .Conclusion:In the treatment of shock, norepinephrine has more obvious advantages in terms of stabilizing the heart rate and reducing renal damage compared with dopamine, which is the best drug to treat shock.