临床精神医学杂志
臨床精神醫學雜誌
림상정신의학잡지
JOURNAL OF CLINICAL PSYCHOLOGICAL MEDICINE
2015年
2期
111-113
,共3页
佐匹克隆%老年期痴呆%睡眠障碍%多导睡眠图
佐匹剋隆%老年期癡呆%睡眠障礙%多導睡眠圖
좌필극륭%노년기치태%수면장애%다도수면도
zopiclone%seniledementia%sleepdisorders%polysomnography
目的：观察佐匹克隆与阿普唑仑对照治疗伴睡眠障碍的老年期痴呆患者的临床疗效与不良反应。方法：将72例老年期痴呆睡眠障碍的患者以随机数字表法分为2组，研究组39例，每晚睡前15 min口服佐匹克隆片7.5 mg/d；对照组33例，每晚睡前15 min口服阿普唑仑片0.4 mg/d，两组疗程均为3周；采用多导睡眠图评价疗效，不良反应量表（ TESS）评价不良反应。结果：研究组与对照组治疗后各睡眠参数较治疗前均有好转（P<0.01）；两组间比较差异无统计学意义（P>0.05）。治疗过程中佐匹克隆组除口腔苦味感外的不良反应发生率（20.51%）低于对照组（60.61%，χ2=11.39，P <0.01），佐匹克隆组口腔苦味感发生率（100%）高于阿普唑伦组（3.03%，P<0.01）。结论：佐匹克隆与阿普唑仑能够缩短伴睡眠障碍的老年期痴呆患者入睡时间，提高睡眠的质量，疗效相当。但佐匹克隆除口腔苦味感明显外，其他不良反应较少。
目的：觀察佐匹剋隆與阿普唑崙對照治療伴睡眠障礙的老年期癡呆患者的臨床療效與不良反應。方法：將72例老年期癡呆睡眠障礙的患者以隨機數字錶法分為2組，研究組39例，每晚睡前15 min口服佐匹剋隆片7.5 mg/d；對照組33例，每晚睡前15 min口服阿普唑崙片0.4 mg/d，兩組療程均為3週；採用多導睡眠圖評價療效，不良反應量錶（ TESS）評價不良反應。結果：研究組與對照組治療後各睡眠參數較治療前均有好轉（P<0.01）；兩組間比較差異無統計學意義（P>0.05）。治療過程中佐匹剋隆組除口腔苦味感外的不良反應髮生率（20.51%）低于對照組（60.61%，χ2=11.39，P <0.01），佐匹剋隆組口腔苦味感髮生率（100%）高于阿普唑倫組（3.03%，P<0.01）。結論：佐匹剋隆與阿普唑崙能夠縮短伴睡眠障礙的老年期癡呆患者入睡時間，提高睡眠的質量，療效相噹。但佐匹剋隆除口腔苦味感明顯外，其他不良反應較少。
목적：관찰좌필극륭여아보서륜대조치료반수면장애적노년기치태환자적림상료효여불량반응。방법：장72례노년기치태수면장애적환자이수궤수자표법분위2조，연구조39례，매만수전15 min구복좌필극륭편7.5 mg/d；대조조33례，매만수전15 min구복아보서륜편0.4 mg/d，량조료정균위3주；채용다도수면도평개료효，불량반응량표（ TESS）평개불량반응。결과：연구조여대조조치료후각수면삼수교치료전균유호전（P<0.01）；량조간비교차이무통계학의의（P>0.05）。치료과정중좌필극륭조제구강고미감외적불량반응발생솔（20.51%）저우대조조（60.61%，χ2=11.39，P <0.01），좌필극륭조구강고미감발생솔（100%）고우아보서륜조（3.03%，P<0.01）。결론：좌필극륭여아보서륜능구축단반수면장애적노년기치태환자입수시간，제고수면적질량，료효상당。단좌필극륭제구강고미감명현외，기타불량반응교소。
Objective:To observe the therapeutic efficiency and adverse effects of zopiclone and alprazo-lam for treatment of patients with senile dementia in sleep disorders. Method:72 cases of patients with senile dementia in sleep disorders were randomly divided into two group. 39 cases of study group,15 minutes every night before going to bed oral zopiclone tablets 7. 5mg/d;33 cases in the control group,15 minutes every night before going to bed oral alprazolam tablets 0. 4mg/d,two groups were treated for 3 weeks;using polysomnogra-phy evaluation of efficacy and treatment emergent symptome scale( TESS)evaluation of the adverse reaction. Results:Study group and control group after treatment than before treatment of various sleep parameters were improved(P<0. 01);difference between the two groups was not statistically significant(P>0. 05). Control group during the treatment of adverse reactions was 60. 61%(20/33);study group adverse reaction rate was 20. 51%(8/39),the difference between the two groups incidence of adverse reactions was statistically signifi-cant(χ2 =11. 39,P<0. 01). But all of zopiclone tablets oral bitter feeling. Conclusion:Zopiclone and al-prazolam can be shortened with sleep disorders in patients with senile dementia in sleep disorders onset time, improve sleep quality and efficacy. Zopiclone among oral sense of bitterness evident,less other adverse reac-tions.
