世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2015年
4期
494-498
,共5页
樊海龙%赵凌%任玉兰%梁繁荣
樊海龍%趙凌%任玉蘭%樑繁榮
번해룡%조릉%임옥란%량번영
针灸%心肌缺血再灌注损伤%线粒体功能障碍%线粒体通路%细胞信号转导
針灸%心肌缺血再灌註損傷%線粒體功能障礙%線粒體通路%細胞信號轉導
침구%심기결혈재관주손상%선립체공능장애%선립체통로%세포신호전도
Acu-moxibustion%Myocardial ischemia-reperfusion injury%Mitochondrial dysfunction%Mitochondrial Pathway%Cel-lular signal transduction
目的:探讨针灸防治心肌缺血再灌注损伤的线粒体细胞信号转导机制,为后续研究提供思路。方法:通过对近年来国内外有关线粒体心脏损伤的研究入手,分析针灸防治心肌缺血再灌注损伤的线粒体通路的研究进展。结果:研究多以大鼠为观察对象,主要从针刺改善线粒体功能,减少线粒体活性氧类(ROS)产生过量引起氧化应激,防止细胞内 Ca2+超载和阻止线粒体通透性转换孔(mPTP)的开放等角度切入研究。结论:微小 RNA(microRNA,miRNA)是基因网络、蛋白网络、代谢网络等的上游网络的调控环节。鉴于针灸作用的整体性特点,将 miRNA 引入针灸作用机制研究领域,可在基因或其他水平层面更好地揭示针灸作用机制。
目的:探討針灸防治心肌缺血再灌註損傷的線粒體細胞信號轉導機製,為後續研究提供思路。方法:通過對近年來國內外有關線粒體心髒損傷的研究入手,分析針灸防治心肌缺血再灌註損傷的線粒體通路的研究進展。結果:研究多以大鼠為觀察對象,主要從針刺改善線粒體功能,減少線粒體活性氧類(ROS)產生過量引起氧化應激,防止細胞內 Ca2+超載和阻止線粒體通透性轉換孔(mPTP)的開放等角度切入研究。結論:微小 RNA(microRNA,miRNA)是基因網絡、蛋白網絡、代謝網絡等的上遊網絡的調控環節。鑒于針灸作用的整體性特點,將 miRNA 引入針灸作用機製研究領域,可在基因或其他水平層麵更好地揭示針灸作用機製。
목적:탐토침구방치심기결혈재관주손상적선립체세포신호전도궤제,위후속연구제공사로。방법:통과대근년래국내외유관선립체심장손상적연구입수,분석침구방치심기결혈재관주손상적선립체통로적연구진전。결과:연구다이대서위관찰대상,주요종침자개선선립체공능,감소선립체활성양류(ROS)산생과량인기양화응격,방지세포내 Ca2+초재화조지선립체통투성전환공(mPTP)적개방등각도절입연구。결론:미소 RNA(microRNA,miRNA)시기인망락、단백망락、대사망락등적상유망락적조공배절。감우침구작용적정체성특점,장 miRNA 인입침구작용궤제연구영역,가재기인혹기타수평층면경호지게시침구작용궤제。
Objective:To investigate acu-moxibustion protection of mitochondrial cellular signal transduction dysfunction due to myocardial ischemia-reperfusion injury.Methods:The research was made by studying research results published in recent years. Results:Most research used rats as study subjects and found acupuncture can improve mitochondria function,reduce mitochondrial reactive oxygen species (ROS)which caused excessive oxidative stress,prevent the intracellular Ca2 + overload and the mitochon-drial permeability transition pore (mPTP)open.Conclusion:MicroRNA (miRNA)is the control factor of such upstream networks as genetic networks,protein networks,and metabolic networks.Given the overall characteristics of acupuncture effect,introducing the miRNA into the acupuncture mechanism research can better reveal acupuncture mechanism.