CAJ | 학술논문

目的：分析总结防己自汉代至今的临床用量变化轨迹及特点，为该药的临床合理使用提供一定的依据。方法：选取汉代至今，最具代表性的医学著作及相关文献为研究对象，建立防己历代用量数据库，分别按各历史朝代对其最大用量、最小用量、平均用量、最常用量及常用量上限、下限进行统计，并结合文献对结果进行阐释与分析。结果：防己用量在汉唐时期呈现“广剂量，宽范围”的特点。从唐末开始，由于散剂普及，防己用量也随之大幅缩减。直至明代，汤剂又开始成为中药的主要剂型，防己用量也渐次回升，但常用量范围仍较为狭窄。结论：防己的平均用量随所处朝代呈现显著变化，但对于病属风湿、水肿重症者，历代医家均有大剂量、超剂量使用者。
목적：분석총결방기자한대지금적림상용량변화궤적급특점，위해약적림상합리사용제공일정적의거。방법：선취한대지금，최구대표성적의학저작급상관문헌위연구대상，건립방기역대용량수거고，분별안각역사조대대기최대용량、최소용량、평균용량、최상용량급상용량상한、하한진행통계，병결합문헌대결과진행천석여분석。결과：방기용량재한당시기정현“엄제량，관범위”적특점。종당말개시，유우산제보급，방기용량야수지대폭축감。직지명대，탕제우개시성위중약적주요제형，방기용량야점차회승，단상용량범위잉교위협착。결론：방기적평균용량수소처조대정현현저변화，단대우병속풍습、수종중증자，역대의가균유대제량、초제량사용자。
Objective:To analyze the dosage and its characteristic of Fangji in different era,in order to provide the basis for clini-cal use of Fangji.Methods:The most representative medical works of each dynasty were selected,and the data base of the usage and dosage of Fang Ji was established.Maximal dosage,minimal dosage,average dosage,most common dosage,upper limit value of common usage and lower limit value of common usage of Fangji were statistically analyzed.Results:The dosage of Fangji in Han and Tang dynasties was large and broad,then decreased sharply from the late Tang dynasty,because of the prevalent of pulvis. Till Ming dynasty,as the main preparation changed form revert to decoction again,the dosage rose gradually,but the rage of com-mon dosage was still narrow.Conclusion:The average dosage of Fangji was changed obviously in different era,meanwhile,large dose and even overdose existed in every era,which were used to treat severe cases of rheumatism or hydroncus.