CAJ | 학술논문

目的：探讨改良电休克治疗（ MECT）对精神分裂症（ SZ）患者血清胶质源性神经营养因子（ GDNF）水平的影响。方法：采用酶联免疫吸附法，对48名正常人（对照组）和70例SZ患者（患者组）在 MECT 前后进行血清 GDNF 水平检测。结果：MECT 前，患者组血清 GDNF 水平[（34.98±20.36）ng/ml]显著低于对照组[（78.23±40.57）ng/ml]（t=6.821，P<0.001）。MECT后，患者组血清GDNF水平[（79.88±36.10）ng/ml]显著升高，与MECT前比较有显著差异（t=-10.64，P<0.01），与对照组差异无统计学意义（t=-0.232，P>0.05）。结论：SZ患者可能存在血清 GDNF水平低下， MECT可能通过提高GDNF水平起作用。
목적：탐토개량전휴극치료（ MECT）대정신분렬증（ SZ）환자혈청효질원성신경영양인자（ GDNF）수평적영향。방법：채용매련면역흡부법，대48명정상인（대조조）화70례SZ환자（환자조）재 MECT 전후진행혈청 GDNF 수평검측。결과：MECT 전，환자조혈청 GDNF 수평[（34.98±20.36）ng/ml]현저저우대조조[（78.23±40.57）ng/ml]（t=6.821，P<0.001）。MECT후，환자조혈청GDNF수평[（79.88±36.10）ng/ml]현저승고，여MECT전비교유현저차이（t=-10.64，P<0.01），여대조조차이무통계학의의（t=-0.232，P>0.05）。결론：SZ환자가능존재혈청 GDNF수평저하， MECT가능통과제고GDNF수평기작용。
Objective:To explore the effect of modified electroconvulsive therapy( MECT)on serum gli-al derived neurotrophic factor( GDNF)in schizophrenic patients( SZ). Method:The serum GDNF levels were measured by enzyme-linked immunosorbent assay in 70 SZ patients( patient group)before and after MECT and 48 normal controls( normal group). Results:Before MECT,the serum GDNF levels in patient group [(34. 98 ± 20. 36)ng/ml]were significantly lower than the levels in normal group[(78. 23 ± 40. 57)ng/ml, t=6. 821,P<0. 001]. After MECT,the serum GDNF levels were significantly increased compared to before MECT in patient group[(79. 88 ± 36. 10)ng/ml,t= -10. 64,P<0. 01]. Moreover,there was no significant difference between the patient group and normal group after MECT(t= -0. 232,P>0. 05). Conclusion:The SZ patients maybe have lower GDNF levels and MECT can increase the serum GDNF concentrations.