CAJ | 학술논문

目的：探讨脑复明滴丸对血管性痴呆大鼠学习记忆能力的影响。方法：采用双侧颈总动脉结扎建立血管性痴呆模型，以安理申作为阳性对照药物。60只 SD 大鼠随机分为假手术组、模型组、脑复明滴丸高剂量组、脑复明滴丸中剂量组、脑复明滴丸低剂量组、阳性药对照组。采用 Morris 水迷宫试验和跳台实验检测大鼠的学习记忆能力。结果：在 Morris 水迷宫实验中，脑复明滴丸可显著缩短总路程与逃避潜伏期，并且显著延长痴呆大鼠在目标象限的停留时间。在跳台实验中，脑复明滴丸能够显著缩短痴呆大鼠的潜伏期。结论：脑复明滴丸对血管性痴呆大鼠学习和记忆功能有改善作用。
목적：탐토뇌복명적환대혈관성치태대서학습기억능력적영향。방법：채용쌍측경총동맥결찰건립혈관성치태모형，이안리신작위양성대조약물。60지 SD 대서수궤분위가수술조、모형조、뇌복명적환고제량조、뇌복명적환중제량조、뇌복명적환저제량조、양성약대조조。채용 Morris 수미궁시험화도태실험검측대서적학습기억능력。결과：재 Morris 수미궁실험중，뇌복명적환가현저축단총로정여도피잠복기，병차현저연장치태대서재목표상한적정류시간。재도태실험중，뇌복명적환능구현저축단치태대서적잠복기。결론：뇌복명적환대혈관성치태대서학습화기억공능유개선작용。
Objective:To explore the effect of Naofuming pill (NFM)on abilities of learning and memorizing of rats with vascular dementia(VD).Methods:VD model of rats was induced by ligation of bilateral common carotid arteries.Aricept was as used positive control drug.Rats were randomly divided into sham operation group,model group,NFM high dose group,NFM middle dose group,NFMlow dose group,as well as positive control group.The ability of learning and memorizing of rats were examined by Morris water maze test and step-down test.Results:In the Morris water maze test,NFM significantly shortened the total dis-tance and the escape latency,and prolonged the residence time in the target quadrant.In the diving platform experiment,com-pared with model group rats,NFMsignificantly reduced latency.Conclusion:NFMcan improve ability of learning and memoring in rats with VD.