CAJ | 학술논문

目的：观察丹红注射液对脑梗死的临床疗效并探讨其作用机制。方法：脑梗死患者202例，随机分为对照组、治疗组。对照组口服肠溶阿司匹林，静脉滴注依达拉奉＋甘露醇；治疗组在此基础上加用丹红注射液；测定治疗前及治疗2周（W）后一氧化氮合成酶（NOS）及超氧化物歧化酶（SOD）含量，测定血液流变学指标并动态观测局部脑血流（rCBF），记录2组病例治疗前后神经功能缺损评分并比较其疗效。结果：丹红注射液能显著增加 SOD 及 NOS 含量，提高 rCBF，神经功能缺损评分明显好转，与对照组比较均有统计学意义（P ＜0.05）结论：丹红注射液可降低脑梗死后脂质过氧化、具有清除氧自由基、改善局部脑血流，对脑梗死有理想的疗效。
목적：관찰단홍주사액대뇌경사적림상료효병탐토기작용궤제。방법：뇌경사환자202례，수궤분위대조조、치료조。대조조구복장용아사필림，정맥적주의체랍봉＋감로순；치료조재차기출상가용단홍주사액；측정치료전급치료2주（W）후일양화담합성매（NOS）급초양화물기화매（SOD）함량，측정혈액류변학지표병동태관측국부뇌혈류（rCBF），기록2조병례치료전후신경공능결손평분병비교기료효。결과：단홍주사액능현저증가 SOD 급 NOS 함량，제고 rCBF，신경공능결손평분명현호전，여대조조비교균유통계학의의（P ＜0.05）결론：단홍주사액가강저뇌경사후지질과양화、구유청제양자유기、개선국부뇌혈류，대뇌경사유이상적료효。
Objective:To observe the clinical effects of Dan Hong Injection on cerebral infarction and to explore its action mecha-nism.Methods:A total of 202 patients with cerebral infarction were randomly divided into control group and treatment group.Con-trol group took oral aspirin and intravenous drip in adr + mannitol;the treatment group took Dan Hong Injection in addition to abovementioned treatments;after 2 weeks (W)treatment,we measured nitric oxide synthase (NOS)and superoxide dismutase (SOD)content,determined blood rheology indicators and regional cerebral blood flow (rCBF),nerve dysfunction scoring and com-pared the curative effect.Results:Compared with that of the control group),Dan Hong Injection could significantly increase SOD and NOS,improve rCBF and neural function defect score.Conclusion:Dan Hong Injection can decrease the lipid peroxidation after cerebral infarction,remove oxygen free radicals,improve regional cerebral blood flow,therefore have ideal efficacy on cerebral in-farction.