临床精神医学杂志
臨床精神醫學雜誌
림상정신의학잡지
JOURNAL OF CLINICAL PSYCHOLOGICAL MEDICINE
2015年
2期
119-122
,共4页
改良电休克%精神分裂症%视觉P300%认知
改良電休剋%精神分裂癥%視覺P300%認知
개량전휴극%정신분렬증%시각P300%인지
modifiedelectroconvulsivetherapy%schizophrenia%visualP300%cognition
目的：观察改良电休克治疗（ MECT）对精神分裂症患者前后视觉P300的变化，探讨MECT对精神分裂症患者的认知功能的影响。方法：选择80例精神分裂症患者入MECT组，单纯药物治疗者80例纳入药物组，另选医院职工20例作为正常对照组，所有研究对象均在治疗前进行1次P300检查，MECT组及药物组治疗1、4、8周后再次进行P300检查。结果：治疗前同正常对照组比较，MECT组与药物组均表现出视觉P300潜伏期显著延长（P<0.05），波幅明显降低（P<0.05），MECT组同药物组之间差异无统计学意义（P>0.05）。MECT组治疗后1周P300潜伏期、波幅、BPRS总分、焦虑抑郁、思维障碍及激活因子分较治疗前显著性改善（ P<0.05）。药物组治疗1周各监测指标与治疗前差异无统计学意义，治疗4周后一些指标才出现差异。治疗8周MECT组与药物组BPRS总分及各因子分与治疗前差值差异无统计学意义。治疗8周后，MECT组与药物组总有效率差异无统计学意义（90.0%和83.8%，χ2=1.37，P>0.05）。结论：MECT控制精神分裂症症状较单纯使用药物治疗起效快，并可能对部分认知功能有改善作用。
目的：觀察改良電休剋治療（ MECT）對精神分裂癥患者前後視覺P300的變化，探討MECT對精神分裂癥患者的認知功能的影響。方法：選擇80例精神分裂癥患者入MECT組，單純藥物治療者80例納入藥物組，另選醫院職工20例作為正常對照組，所有研究對象均在治療前進行1次P300檢查，MECT組及藥物組治療1、4、8週後再次進行P300檢查。結果：治療前同正常對照組比較，MECT組與藥物組均錶現齣視覺P300潛伏期顯著延長（P<0.05），波幅明顯降低（P<0.05），MECT組同藥物組之間差異無統計學意義（P>0.05）。MECT組治療後1週P300潛伏期、波幅、BPRS總分、焦慮抑鬱、思維障礙及激活因子分較治療前顯著性改善（ P<0.05）。藥物組治療1週各鑑測指標與治療前差異無統計學意義，治療4週後一些指標纔齣現差異。治療8週MECT組與藥物組BPRS總分及各因子分與治療前差值差異無統計學意義。治療8週後，MECT組與藥物組總有效率差異無統計學意義（90.0%和83.8%，χ2=1.37，P>0.05）。結論：MECT控製精神分裂癥癥狀較單純使用藥物治療起效快，併可能對部分認知功能有改善作用。
목적：관찰개량전휴극치료（ MECT）대정신분렬증환자전후시각P300적변화，탐토MECT대정신분렬증환자적인지공능적영향。방법：선택80례정신분렬증환자입MECT조，단순약물치료자80례납입약물조，령선의원직공20례작위정상대조조，소유연구대상균재치료전진행1차P300검사，MECT조급약물조치료1、4、8주후재차진행P300검사。결과：치료전동정상대조조비교，MECT조여약물조균표현출시각P300잠복기현저연장（P<0.05），파폭명현강저（P<0.05），MECT조동약물조지간차이무통계학의의（P>0.05）。MECT조치료후1주P300잠복기、파폭、BPRS총분、초필억욱、사유장애급격활인자분교치료전현저성개선（ P<0.05）。약물조치료1주각감측지표여치료전차이무통계학의의，치료4주후일사지표재출현차이。치료8주MECT조여약물조BPRS총분급각인자분여치료전차치차이무통계학의의。치료8주후，MECT조여약물조총유효솔차이무통계학의의（90.0%화83.8%，χ2=1.37，P>0.05）。결론：MECT공제정신분렬증증상교단순사용약물치료기효쾌，병가능대부분인지공능유개선작용。
Objective:To observe the effect of modified electroconvulsive therapy( MECT ) on the change of the visual P300 and to investigate the effects of MECT on cognitive function in schizophrenia patients. Method:Eighty patients with schizophrenia was in the MECT group,80 cases with simple use drugs treatment were in the drug group and 20 healthy hospital staff members were in normal control group. P300 examination was adminsteredin all groups before treatment,and after 1,4,8 weeks treatment in MECT group and drug group. Results:Before treatment,MECT and drug group showed significantly prolonged visual P300 latencies (P<0. 05)and decreased amplitudes(P<0. 05)compared with the normal control group,but no significant difference was found between the MECT and the drug group(P>0. 05). One week after treatment,P300 laten-cy,amplitude,BPRS total score,anxiety and depression,thought disorder and activation factor scores were signif-icantly improved in MECT group(P<0. 05). Drug group showed no significant difference after 1 week treat-ment,but some monitoring index showed significant difference after 4 week treatment. After 8 weeks treatment, MECT group and drug group showed no significant difference between before and after treatment on BPRS total score and each factor score. After 8 weeks of treatment,MECT group and the drug group showed no significant difference on the total effective rate(90% vs 83. 8%,χ2 =1. 37,P>0. 05). Conclusion:MECT and drug therapy can improve psychotic symptoms sooner than drug therapy only,and also improve the partial cognition function.
