CAJ | 학술논문

目的：分析TIP30和血管内皮生长因子－C（ VEGF－C）在局限期小细胞肺癌（ SCLC）中的表达和临床意义。方法免疫组化法检测68例SCLC原发灶中TIP30和VEGF－C的表达。结果68例SCLC组织中TIP30和VEGF－C阳性表达率分别为51．5％（35／68）、54．4％（37／68）。 VEGF－C表达与淋巴结转移和肿瘤大小相关（P＜0．05），与患者的年龄、性别和吸烟之间差异无统计学意义（P＞0．05）。TIP30表达与患者的年龄、性别、吸烟、淋巴结转移和肿瘤大小之间的差异无统计学意义（ P＞0．05）。VEGF－C与TIP30表达呈负相关。 TIP30表达阳性SCLC患者的DFS和OS较长。相反，VEGF－C表达阳性SCLC患者的DFS和OS较短。 Cox多因素分析提示TIP30和VEGF－C表达是SCLC独立不良预后因素（P＜0．01）。结论 VEGF－C表达与淋巴结转移相关，TIP30阴性和VEGF－C阳性表达的SCLC患者预后差。
목적：분석TIP30화혈관내피생장인자－C（ VEGF－C）재국한기소세포폐암（ SCLC）중적표체화림상의의。방법면역조화법검측68례SCLC원발조중TIP30화VEGF－C적표체。결과68례SCLC조직중TIP30화VEGF－C양성표체솔분별위51．5％（35／68）、54．4％（37／68）。 VEGF－C표체여림파결전이화종류대소상관（P＜0．05），여환자적년령、성별화흡연지간차이무통계학의의（P＞0．05）。TIP30표체여환자적년령、성별、흡연、림파결전이화종류대소지간적차이무통계학의의（ P＞0．05）。VEGF－C여TIP30표체정부상관。 TIP30표체양성SCLC환자적DFS화OS교장。상반，VEGF－C표체양성SCLC환자적DFS화OS교단。 Cox다인소분석제시TIP30화VEGF－C표체시SCLC독립불량예후인소（P＜0．01）。결론 VEGF－C표체여림파결전이상관，TIP30음성화VEGF－C양성표체적SCLC환자예후차。
Objective To investigate the correlation between TIP 30 and VEGF-C expression and clini-cophathological characteristics in resected small cell lung cancer ( SCLC) patients and to identify patients with in-creased risk of cancer recurrence and to provide a theoretical basis for the further clinical prevention of SCLC . Methods Sixty eight resected SCLC patients were included in this study .Paraffin-embedded specimens of pa-tients were used for the evaluation of TIP 30 and VEGF-C expression by immunohistochemistry .Results The expression of VEGF-C had positive correlation with lymph node metastasis .TIP30 expression was positively cor-related with VEGF-C expression.Patients with low TIP30 expression had shorter Overall survival (OS)and Dis-ease-Free survival(DFS)than those with high TIP30 expression.OS and DFS of the patients with VEGF -C-positive tumors were significantly lower than that of the patients with VEGF -C negative tumors .The multivariate Cox regression analysis showed that low TIP 30 and high VEGF-C expression were independent markers of poor OS(P<0.01)in operable SCLC patients.Conclusion The expression of VEGF -C shows positive correlation with lymph node metastasis .Low TIP30 and high VEGF -C expression are independent prognostic markers of poor overall survival in resected SCLC patients .