CAJ | 학술논문

目的：通过分析单抗类抗肿瘤药使用情况，了解其使用现状、短期疗效及不良反应，为临床合理用药提供参考。方法收集2013年上半年中山市某三甲医院使用单抗类抗肿瘤药物的病例310例，摘录患者基本资料、用药情况及治疗期间出现的不良反应，对其使用情况进行分析，并结合住院时长分析短期疗效。结果单抗类抗肿瘤药物收费数量、金额占抗肿瘤药物收费总数量、总金额的0．12％和13．67％左右。241例（78％）单次疗程住院时长在14天以内，没有出现严重不良反应。298例（96％）顺利完成化疗疗程。结论单抗类抗肿瘤药物临床疗效良好，不良反应多为轻中度化疗反应，经处理后能恢复，但由于价格昂贵，限制了临床的应用。
목적：통과분석단항류항종류약사용정황，료해기사용현상、단기료효급불량반응，위림상합리용약제공삼고。방법수집2013년상반년중산시모삼갑의원사용단항류항종류약물적병례310례，적록환자기본자료、용약정황급치료기간출현적불량반응，대기사용정황진행분석，병결합주원시장분석단기료효。결과단항류항종류약물수비수량、금액점항종류약물수비총수량、총금액적0．12％화13．67％좌우。241례（78％）단차료정주원시장재14천이내，몰유출현엄중불량반응。298례（96％）순리완성화료료정。결론단항류항종류약물림상료효량호，불량반응다위경중도화료반응，경처리후능회복，단유우개격앙귀，한제료림상적응용。
Objective To know the current situation of the Monoclonal antibodies target anticancer drugs by collecting and analyzing data,to provide reference for the clinical reasonable application .Methods We collected 310 cases used the antibodies target anticancer drugs in the hospital of ZhongShan , analyzed its clinical efficacy, and evaluated the drugs'efficacy combining the time be hospitalized .Results The sum and number of charges of the Monoclonal antibodies targeted anticancer drugs are 13.67 percent and 0.12 percent in the total charges of anticancer drugs.There are 241 cases (78%) hospitalized in a single course of treatment within 14 days; 298(96%) comple-ted the chemotherapy successfully .Conclusion The monoclonal antibodies targeting anticancer drugs has the good clinical efficacy, and most of the adverse reactions are mild or moderate which can recover after treated .The key fac-tor limited the clinical application of the monoclonal antibodies targeted anticancer drugs is the price .