CAJ | 학술논문

目的：探讨T细胞亚群前后曲线变化与胃癌根治术后感染性并发症的关系。方法分析2012年2月—2014年2月在辽宁省盘锦市中心医院接受外科手术治疗的70例胃癌患者的临床资料。根据患者术后是否出现感染性并发症分为观察组（出现并发症的患者）和对照组（无并发症的患者）。比较两组患者的T淋巴细胞的亚群结果。结果本研究共纳入患者70例，其中观察组33例，对照组37例。术后4 d时，观察组患者的CD3显著低于对照组（P＜0．05），其余时间段并无统计学差异（P＞0．05）；术后4 d时，观察组患者的CD4水平显著低于对照组（P＜0．05），其余时间段并无统计学差异（P＞0．05）；术后4 d（P＜0．01）和术后9 d（P＜0．05）时，观察组患者的CD8水平低于对照组，其余时间段并无统计学差异（P＞0．05）；术后4 d（P＜0．05）和术后9 d（P＜0．05）时，观察组患者的CD4／CD8水平低于对照组，其余时间段并无统计学差异（ P＞0．05）。结论 T淋巴细胞亚群术前、术后的曲线变化与胃癌根治术后感染性并发症的发生率有着显著的相关性。
목적：탐토T세포아군전후곡선변화여위암근치술후감염성병발증적관계。방법분석2012년2월—2014년2월재요녕성반금시중심의원접수외과수술치료적70례위암환자적림상자료。근거환자술후시부출현감염성병발증분위관찰조（출현병발증적환자）화대조조（무병발증적환자）。비교량조환자적T림파세포적아군결과。결과본연구공납입환자70례，기중관찰조33례，대조조37례。술후4 d시，관찰조환자적CD3현저저우대조조（P＜0．05），기여시간단병무통계학차이（P＞0．05）；술후4 d시，관찰조환자적CD4수평현저저우대조조（P＜0．05），기여시간단병무통계학차이（P＞0．05）；술후4 d（P＜0．01）화술후9 d（P＜0．05）시，관찰조환자적CD8수평저우대조조，기여시간단병무통계학차이（P＞0．05）；술후4 d（P＜0．05）화술후9 d（P＜0．05）시，관찰조환자적CD4／CD8수평저우대조조，기여시간단병무통계학차이（ P＞0．05）。결론 T림파세포아군술전、술후적곡선변화여위암근치술후감염성병발증적발생솔유착현저적상관성。
Objective Our retrospective study is aimed to discuss the relationship between the curve changes of T lymphocyte subsets before and after the operation and the infectious complications after radical resec -tion of gastric cancer .Methods Clinical data of patients with gastric cancer received treatment at Central Hospi -tal of Panjin City,Liaoning Province from 2012 to 2014 were retrospectively analyzed .The enrolled patients were divided into two groups according to the infectious complications ,observe group ( patients with infectious complica-tions) and control group ( patients without infectious complications ) .The results of T lymphocyte subsets in two groups were compared .Results A total of 70 patients was retrospective analyzed , including 33 pationts in ob-serve group and 37 pationts in control group.At the 4th day after operation,the levels of CD3,CD4 in the observe group were obviously lower than those in control group .There was no statistical difference at the other time points . At the 4th and 9th day after operation,the levels of CD8,CD4/CD8 rate in the observe group were obviously lower than those in control group .There was no statistical difference at the other time points .Conclusion There is re-markable relationship between the curve changes of T lymphocyte subsets before or after the operation and the in -cidence of infectious complications after radical resection of gastric cancer .