CAJ | 학술논문

目的：探讨奥硝唑联合阿奇霉素对部队官兵炎症性痤疮的临床效果及其对细胞因子 IL-8、TNF-α的影响。方法将180例武警某支队炎症性痤疮患者分为对照组(n =88)与观察组(n =92),对照组采用奥硝唑治疗,观察组在此基础上联合阿奇霉素治疗。比较二组临床疗效、治疗前后皮损严重程度及数量评分、治疗前后 SF-36量表各维度评分、治疗前后血清 IL-8及 TNF-α水平变化、不良反应发生情况。结果①对照组临床总有效率为71.59%,显著小于观察组(94.57%)(P <0.05)；②二组治疗后皮损严重程度及数量(潮红、压痛、炎性丘疹、脓肿、脓疱、粉刺及瘢痕)评分均显著低于治疗前(P <0.05,P <0.01),且观察组治疗后上述评分也均显著小于对照组治疗后(P <0.05)；③二组治疗后 SF-36量表各维度(情感、一般感情指数、健康指数及生活满意度)评分均显著高于治疗前(P <0.05,P <0.01),且观察组治疗后各维度评分均显著高于对照组治疗后(P <0.05)；④二组治疗后血清 IL-8及 TNF-α水平均显著低于治疗前(P <0.05),且观察组治疗后上述指标水平均显著低于对照组治疗后(P <0.05)；⑤对照组不良反应发生率为11.36%,观察组为9.78%,二组差异无统计学意义(P >0.05)。结论奥硝唑联合阿奇霉素可有效降低炎症性痤疮患者血清 IL-8及 TNF-α水平,这可能是该方案取效的重要机制。
목적：탐토오초서연합아기매소대부대관병염증성좌창적림상효과급기대세포인자 IL-8、TNF-α적영향。방법장180례무경모지대염증성좌창환자분위대조조(n =88)여관찰조(n =92),대조조채용오초서치료,관찰조재차기출상연합아기매소치료。비교이조림상료효、치료전후피손엄중정도급수량평분、치료전후 SF-36량표각유도평분、치료전후혈청 IL-8급 TNF-α수평변화、불량반응발생정황。결과①대조조림상총유효솔위71.59%,현저소우관찰조(94.57%)(P <0.05)；②이조치료후피손엄중정도급수량(조홍、압통、염성구진、농종、농포、분자급반흔)평분균현저저우치료전(P <0.05,P <0.01),차관찰조치료후상술평분야균현저소우대조조치료후(P <0.05)；③이조치료후 SF-36량표각유도(정감、일반감정지수、건강지수급생활만의도)평분균현저고우치료전(P <0.05,P <0.01),차관찰조치료후각유도평분균현저고우대조조치료후(P <0.05)；④이조치료후혈청 IL-8급 TNF-α수평균현저저우치료전(P <0.05),차관찰조치료후상술지표수평균현저저우대조조치료후(P <0.05)；⑤대조조불량반응발생솔위11.36%,관찰조위9.78%,이조차이무통계학의의(P >0.05)。결론오초서연합아기매소가유효강저염증성좌창환자혈청 IL-8급 TNF-α수평,저가능시해방안취효적중요궤제。
Objective To investigate the clinical efficacy of the ornidazole combined with azithromycin in the treatment of inflammatory acne for arm police and its impact on the level of cytokine IL - 8,TNF-α. Methods A total of 180 cases of inflammatory acne patients of a detachment of arm police were divided into the control group (n= 88)and the observation group (n= 92)according to the method of treatment.The control group were given ornidazole for treatment only,and the observation group were given azithromycin for treatment on basis of the control group.The clinical efficacy,the number of lesions severity scores,SF-36 scores for each dimension,serum IL-8 and TNF-αlevels and adverse events of the two groups be-fore and after the treatment were compared.Results The total effective rate of the control group was 71. 59%,which was significantly lower than the observation group (94.57%)(P <0.05).After treatment, the severity and number of lesions (flushing,tenderness,inflammatory papules,abscesses,pustules,pim-ples and scars)scores of the two groups were significantly lower than before treatment (P <0.05,after P<0.01),and the above-mentioned scores in the observation group were significantly lower than that in the control group (P <0.05),and there was a same results in serum IL-8 and TNF-αlevels.After treat-ment,SF-36 dimensions (emotional,general feelings index,health and life satisfaction index)scores were significantly higher than before treatment (P <0.05,P <0.01),which were significantly higher in the ob-servation group than that in the control group (P <0.05).In the control group,adverse reaction rate was 11.36%,9.78% in the observation group,the two groups showed no significant difference (P >0.05).Conclusion Ornidazole combined with azithromycin can reduce serum IL-8 and TNF-αlevels of patients with inflammatory acne,which may be an important mechanism for the program to take effect.