CAJ | 학술논문

利用L-赖氨酸上的ε氨基与丙烯酰氯反应，合成了一种包含完整氨基酸单元的两性单体(εACRLLY)，并用1H-NMR、FT-IR、元素分析对该单体进行了表征；将该单体与丙烯酰胺共聚制备了一种具有完整氨基酸侧链的pH敏感的两性聚合物P(εACRLLY-co-AM)。通过研究聚合物溶液表观黏度与pH值、外加盐浓度间的关系，聚合物在溶液中的流体力学直径与溶液pH值间的关系，发现该聚合物表现出显著的pH敏感性，具有明显的两性特征和反聚电解质效应，聚合物的等电点为pH 6.2；聚合物中氨基和羧基在不同pH值下具有不同的电离状态是造成这一性能变化的主要原因。
이용L-뢰안산상적ε안기여병희선록반응，합성료일충포함완정안기산단원적량성단체(εACRLLY)，병용1H-NMR、FT-IR、원소분석대해단체진행료표정；장해단체여병희선알공취제비료일충구유완정안기산측련적pH민감적량성취합물P(εACRLLY-co-AM)。통과연구취합물용액표관점도여pH치、외가염농도간적관계，취합물재용액중적류체역학직경여용액pH치간적관계，발현해취합물표현출현저적pH민감성，구유명현적량성특정화반취전해질효응，취합물적등전점위pH 6.2；취합물중안기화최기재불동pH치하구유불동적전리상태시조성저일성능변화적주요원인。
An ampholytic monomer containing full amino acid units(ε-acryloyl L-lysine(εACRLLY)) was synthesized as a reaction product of acryloyl chloride andε-amino of L-lysine. Its structure was characterized by 1H-NMR, FTIR and elemental analysis. A pH-sensitive ampholytic copolymerP(εACRLLY -co-AM) containing full amino acid side chains was prepared by polymerization ofεACRLLY and acrylamide(AM) through free radical polymerization. The isoelectric point ofP(εACRLLY -co-AM) is 6.2.The changes of the apparent viscosity of the polymer solution with pH and salts concentration, and the change of hydrodynamic diameter at different pH indicate that this polymer is pH-sensitive and has ampholytic and anti-polyelectrolyte effects. These properties are related to the dissociation difference of carboxyl and amino groups on P (εACRLLY -co-AM) molecular chains at different pH values.