CAJ | 학술논문

制备了具有良好油溶性的O-磺化-N,N-双十二烷基壳聚糖（HSDLCS）和O-季铵化-N,N-双十二烷基壳聚糖（QADLCS），研究了 HSDLCS/QADLCS 混合单分子膜和自组装囊泡性质的关系。结果表明，混合单分子膜的崩溃压（46.14mN/m）和最大压缩模量（Cs,max?1，98.85mN/m）较相应的单组分大；自组装形成球形囊泡的粒径在200～400nm；以维生素B12为模型药物制备 HSDLCS/QADLCS复合囊泡的载药量为0.1987mg/mg，包封率为38.25%，药物平衡释放率为23.68%。静电作用使得混合单分子膜的凝聚性和抗形变能力更强，复合囊泡药物通透性降低，结构更紧密。单分子膜的Cs,max?1与其相应载药囊泡药物平衡释放率呈一定的线性关系。
제비료구유량호유용성적O-광화-N,N-쌍십이완기각취당（HSDLCS）화O-계안화-N,N-쌍십이완기각취당（QADLCS），연구료 HSDLCS/QADLCS 혼합단분자막화자조장낭포성질적관계。결과표명，혼합단분자막적붕궤압（46.14mN/m）화최대압축모량（Cs,max?1，98.85mN/m）교상응적단조분대；자조장형성구형낭포적립경재200～400nm；이유생소B12위모형약물제비 HSDLCS/QADLCS복합낭포적재약량위0.1987mg/mg，포봉솔위38.25%，약물평형석방솔위23.68%。정전작용사득혼합단분자막적응취성화항형변능력경강，복합낭포약물통투성강저，결구경긴밀。단분자막적Cs,max?1여기상응재약낭포약물평형석방솔정일정적선성관계。
Oil-solubleO-sulfonated-N,N-dilauryl chitosan (HSDLCS) andO-quaternized-N,N- dilauryl chitosan (QADLCS) with similar substitution were synthesized. The properties of mixed monolayers and self-assembly vesicles of HSDLCS and QADLCS were studied. The mixed monolayers had larger collapse pressure (πc) larger maximum compression modulus (Cs,max?1) and limited molecular area (Aex) compared with HSDLCS and QADLCS monolayers. Spherical self-assembly vesicles were formed in diameter 200—400nm. Using Vitamin B12 as model drug,drug loading and encapsulation efficiency of complex vesicles were 0.1987 mg/mg and 38.25%,and equilibrium rates of Vitamin B12release was 23.68%. Electrostatic attraction existing between the hydrophilic groups of HSDLCS and QADLCS resulted in stronger anti-deformation ability and cohesion of the mixed monolayers,decreased drug permeability of complex vesicles,and more tight structure of vesicles.Therer was a linear relationship between theCs,max?1 of monolayers and equilibrium drug-release rate of the vesicles.