CAJ | 학술논문

纳米银因其高效、广谱、不易产生耐药性、安全性高等优点，成为当前抗菌材料的研究热点之一，但目前对纳米银的抗菌机理仍有不同的认识。本文首先综述了国内外纳米银抗菌机理的研究进展和主要成果，主要从影响细菌生活环境、破坏细菌的细胞壁和细胞膜、抑制DNA复制、抑制酶呼吸作用和抑制其他酶活性5个方面分析了纳米银的抗菌机理。并且纳米银的抗菌过程受多种因素影响，文中详细阐述了纳米银的尺寸分布、形貌以及稳定剂、活性氧、菌种和培养基等因素对纳米银抗菌性的影响。最后指出纳米银的抗菌过程复杂，进一步研究其具体作用方式和机理以及影响抗菌作用的主要因素都将有助于纳米银抗菌材料的广泛应用。
납미은인기고효、엄보、불역산생내약성、안전성고등우점，성위당전항균재료적연구열점지일，단목전대납미은적항균궤리잉유불동적인식。본문수선종술료국내외납미은항균궤리적연구진전화주요성과，주요종영향세균생활배경、파배세균적세포벽화세포막、억제DNA복제、억제매호흡작용화억제기타매활성5개방면분석료납미은적항균궤리。병차납미은적항균과정수다충인소영향，문중상세천술료납미은적척촌분포、형모이급은정제、활성양、균충화배양기등인소대납미은항균성적영향。최후지출납미은적항균과정복잡，진일보연구기구체작용방식화궤리이급영향항균작용적주요인소도장유조우납미은항균재료적엄범응용。
Silver nanoparticles (SNP) have attracted much attention due to its high efficiency,wide spectrum,low drug-resistance to bacteria,and high safety. The research achievements in antibacterial mechanisms of SNP are summarized,starting from the analyses about the antibacterial mechanisms of SNP from the following aspects:effect on living environments of bacteria,destruction of cell wall and cell membrane of bacteria,inhibition of DNA replication,suppression of respiration of enzyme and inhibition of activity of other enzymes. Next,the important factors in the antibacterial properties of SNP are discussed,including the particle size and morphology of SNP,stabilizers, reactive oxygen,culture medium,etc. Lastly,some vital problems and prospects in the study about the antibacterial properties of SNP are indicated.