CAJ | 학술논문

目的：研究一种微波辅助的聚苯乙烯树脂聚乙二醇（PEG）化的方法。方法使用PEG 200对市售Merrifield树脂进行修饰，尝试了不同条件下PEG化的效率。使用自行制备的PEG化树脂进一步衍生化，并进行氨基酸的负载，与市售王树脂进行比对。结果优选出了一套较为合适的反应参数，使用5 g树脂，50 ml PEG 200，微波功率600 W，预设温度170℃，照射15 min，共2次，获得了接近90%的负载率。衍生化得到PEG化王树脂后与氨基酸进行缩合，获得了令人满意的产率。结论本文首次报道了多模微波装置辅助的聚苯乙烯树脂PEG化，该方法操作简单，制备快速，条件温和，产率满意，远远优于传统制备方法。
목적：연구일충미파보조적취분을희수지취을이순（PEG）화적방법。방법사용PEG 200대시수Merrifield수지진행수식，상시료불동조건하PEG화적효솔。사용자행제비적PEG화수지진일보연생화，병진행안기산적부재，여시수왕수지진행비대。결과우선출료일투교위합괄적반응삼수，사용5 g수지，50 ml PEG 200，미파공솔600 W，예설온도170℃，조사15 min，공2차，획득료접근90%적부재솔。연생화득도PEG화왕수지후여안기산진행축합，획득료령인만의적산솔。결론본문수차보도료다모미파장치보조적취분을희수지PEG화，해방법조작간단，제비쾌속，조건온화，산솔만의，원원우우전통제비방법。
Objective To study a method of microwave-assistant PEGylation of polystyrene resin. Methods Modify the commercial Merrifield resin with PEG-200, and study the influence of the yield under different conditions. The self-prepared PEG resin was further derived to PEG-wang resin; kinds of amino acids were anchored, and the loading rates were compared with commercial wang resin. Result A general series react conditions were preferred, which was performed with 5 g resin, 50 ml PEG-200, irradiating for 15 min ×2 at 600 W, preset temperature was 170 ℃. The resin was then transformed to PEGylated Wang resin and anchored with amino acids, the yields were satisfied. Conclusion The multi-mode microwave assistant PEGylation of Merrifield resin method was first reported in this paper. This method has the advantages of simple operation,fast preparation, mild reaction conditions and good yield, which was much better than the traditional method.