CAJ | 학술논문

目的：探讨磁共振动态增强成像（ DCE-MRI）对卵巢肿瘤血管生成及侵袭的诊断价值。方法回顾性分析98例经手术病理证实的卵巢肿瘤患者术前且未经治疗的DCE-MEI影像资料，据药物动力学模型获得病灶的对比剂容积转移常数（ Ktrans ）、血管外细胞外间隙（ Ve）值，采用免疫组织化学检测卵巢肿瘤组织血管内皮生长因子（VEGF）、基质金属蛋白酶-2（MMP-2）表达，并对DCE-MRI参数与免疫组织化学结果进行相关性分析。结果卵巢恶性肿瘤组织中VEGF与MMP-2表达明显高于良性肿瘤（ P＜0.05）；卵巢恶性肿瘤Ktrans与Ve均值亦明显高于良性肿瘤，差异具有统计学意义（ P＜0.05）；Ktrans、Ve与VEGF、MMP-2表达均呈正相关。结论 DCE-MRI能够无创在体评价卵巢肿瘤血管生成及侵袭情况，对临床治疗及预后评估具有重要意义。
목적：탐토자공진동태증강성상（ DCE-MRI）대란소종류혈관생성급침습적진단개치。방법회고성분석98례경수술병리증실적란소종류환자술전차미경치료적DCE-MEI영상자료，거약물동역학모형획득병조적대비제용적전이상수（ Ktrans ）、혈관외세포외간극（ Ve）치，채용면역조직화학검측란소종류조직혈관내피생장인자（VEGF）、기질금속단백매-2（MMP-2）표체，병대DCE-MRI삼수여면역조직화학결과진행상관성분석。결과란소악성종류조직중VEGF여MMP-2표체명현고우량성종류（ P＜0.05）；란소악성종류Ktrans여Ve균치역명현고우량성종류，차이구유통계학의의（ P＜0.05）；Ktrans、Ve여VEGF、MMP-2표체균정정상관。결론 DCE-MRI능구무창재체평개란소종류혈관생성급침습정황，대림상치료급예후평고구유중요의의。
Objective To evaluate the diagnostic value of dynamic contrast enhanced MRI (DCE-MRI)in angiogenesis and invasion of ovarian tumors .Methods 98 patients with pathological-confirmed ovarian tumors without any treatment underwent plain MRI and DCE-MRI before operation .The plain MR images and DCE-MRI data were retrospectively analyzed .Value of Ktrans and Ve was detected by pharmacokinetic model .The expression of VEGF and MMP-2 in ovarian tumors was examined by immunohistochemistry .The correlation between DCE-MRI parameters and immunohistochemical results was analyzed .Results The expression of VEGF and MMP-2 was sig-nificantly higher in the malignant group compared with that in the benign group (both P<0.05).The value of Ktrans and Ve was significantly lower in the benign group compared with that in the malignant group ( both P<0.05) .The value of Ktrans and Ve was positively correlated with the expression of VEGF and MMP-2.Conclusion DCE-MRI can noninvasively evaluate the angiogenesis and invasion of ovarian tumors in vivo , which has important signifi-cance for clinical treatment and prognostic assessment .