CAJ | 학술논문

目的：比较厄贝沙坦氢溴酸盐与厄贝沙坦的毒性和药效。方法采用无创血压测量比较了厄贝沙坦氢溴酸盐、厄贝沙坦对自发性高血压大鼠血压的影响。分别ip、ig给药，观察两种药物的半数致死量（LD50），对心率、呼吸以及动物自主活动的影响。结果自发性高血压大鼠的血压明显高于非自发性高血压大鼠，给予厄贝沙坦氢溴酸盐、厄贝沙坦后血压均降至正常水平，且两种药物的降压作用差异无显著性，但厄贝沙坦氢溴酸盐的药效持续时间更长。厄贝沙坦氢溴酸盐、厄贝沙坦对动物的呼吸、心率以及自主活动的影响无差异，但厄贝沙坦氢溴酸盐的 LD50明显高于厄贝沙坦。结论厄贝沙坦氢溴酸盐具有和厄贝沙坦相同的降压作用，但是作用时间更长，安全性更高。
목적：비교액패사탄경추산염여액패사탄적독성화약효。방법채용무창혈압측량비교료액패사탄경추산염、액패사탄대자발성고혈압대서혈압적영향。분별ip、ig급약，관찰량충약물적반수치사량（LD50），대심솔、호흡이급동물자주활동적영향。결과자발성고혈압대서적혈압명현고우비자발성고혈압대서，급여액패사탄경추산염、액패사탄후혈압균강지정상수평，차량충약물적강압작용차이무현저성，단액패사탄경추산염적약효지속시간경장。액패사탄경추산염、액패사탄대동물적호흡、심솔이급자주활동적영향무차이，단액패사탄경추산염적 LD50명현고우액패사탄。결론액패사탄경추산염구유화액패사탄상동적강압작용，단시작용시간경장，안전성경고。
Objective To compare toxicity and pharmacodynamics between irbesartan and irbesartan hydrobromate.Methods Blood pressures in spontaneously hypertensive rats (SHR) after administered with irbesartan and irbesartan hydrobromate were compared using noninvasive blood pressure. SHR were ip and igadministered with drugs, and effects on heart rate, respiratory rate, and autonomic activities were observed.Results Blood pressure in SHR was higher than that of non spontaneous hypertensive rats. Both irbesartan hydrobromate and irbesartan could lower blood pressure, and there were no differences between two groups, but duration of irbesartan hydrobromate was longer. There was no difference between two groups on heart rate, respiratory rate, and autonomic activities. LD50value of irbesartan hydrobromate was higher than that of irbesartan.Conclusion Irbesartan hydrobromate has anti-hypertensive effect as well as irbesartan, but with longer duration and higher security.