CAJ | 학술논문

目的：探讨辛伐他汀与氯沙坦联合应用对原发性高血压合并左室肥厚患者的治疗效果。方法90例原发性高血压合并左室肥厚患者随机分为观察组和对照组，每组45例。观察组予以辛伐他汀联合氯沙坦治疗，对照组予以氯沙坦治疗。比较两组治疗前后血压及舒张末期左室后壁厚度(LVPWT)、舒张末期室间隔厚度(IVST)、舒张末期左室腔内径(LVDd)和左心室质量指数(LVMI)的变化情况。结果两组治疗后收缩压及舒张压水平比治疗前明显下降，差异具有统计学意义(P<0.05)，观察组治疗后收缩压及舒张压水平明显低于对照组(P<0.05)。两组治疗后LVPWT、IVST、LVDd及LVMI水平比治疗前明显下降，差异具有统计学意义(P<0.05)；观察组治疗后LVPWT、IVST、LVDd及LVMI水平均明显低于对照组(P<0.05)。结论在应用氯沙坦基础上联合辛伐他汀治疗，可显著提高对原发性高血压合并左室肥厚患者的治疗效果，值得临床推广应用。
목적：탐토신벌타정여록사탄연합응용대원발성고혈압합병좌실비후환자적치료효과。방법90례원발성고혈압합병좌실비후환자수궤분위관찰조화대조조，매조45례。관찰조여이신벌타정연합록사탄치료，대조조여이록사탄치료。비교량조치료전후혈압급서장말기좌실후벽후도(LVPWT)、서장말기실간격후도(IVST)、서장말기좌실강내경(LVDd)화좌심실질량지수(LVMI)적변화정황。결과량조치료후수축압급서장압수평비치료전명현하강，차이구유통계학의의(P<0.05)，관찰조치료후수축압급서장압수평명현저우대조조(P<0.05)。량조치료후LVPWT、IVST、LVDd급LVMI수평비치료전명현하강，차이구유통계학의의(P<0.05)；관찰조치료후LVPWT、IVST、LVDd급LVMI수평균명현저우대조조(P<0.05)。결론재응용록사탄기출상연합신벌타정치료，가현저제고대원발성고혈압합병좌실비후환자적치료효과，치득림상추엄응용。
Objective To investigate the curative effect of simvastatin combined with losartan in the treatment of primary hypertension complicated with left ventricular hypertrophy.Methods A total of 90 patients of primary hypertension complicated with left ventricular hypertrophy were randomly divided into observation group and control group, with 45 cases in each group. The observation group received simvastatin combined with losartan for treatment, and the control group received losartan alone. Comparisons were made on the changes of blood pressure, diastasis left ventricular posterior wall thickness (LVPWT), diastasis interventricular septum thickness (IVST), diastasis left ventricular diastolic diameter (LVDd), and left ventricular mass index (LVMI) before and after treatment in the two groups.Results After treatment, both groups had decreased systolic pressure and diastolic pressure levels compared with those before treatment, and the difference had statistical significance (P<0.05). Those in the observation group were all lower than the control group after treatment (P<0.05). Both groups had decreased LVPWT, IVST, LVDd, and LVMI levels after treatment than those before treatment, and the difference had statistical significance (P<0.05). The observation group had much lower levels of LVPWT, IVST, LVDd, and LVMI than the control group after treatment (P<0.05).Conclusion Combined application of simvastatin and losartan can remarkably improve curative effect for primary hypertension complicated with left ventricular hypertrophy, and this method is worthy of clinical promotion and application.