现代药物与临床
現代藥物與臨床
현대약물여림상
Drugs & Clinic
2015年
4期
429-432
,共4页
盐酸川芎嗪注射液%甲钴胺片%股外侧皮神经炎
鹽痠川芎嗪註射液%甲鈷胺片%股外側皮神經炎
염산천궁진주사액%갑고알편%고외측피신경염
Ligustrazine Hydrochloride Injection%Mecobalamin Tablets%lateral femoral cutaneous neuritis
目的：探讨盐酸川芎嗪联合甲钴胺治疗股外侧皮神经炎的临床疗效。方法选取2013年9月—2014年9月哈尔滨理工大学校医院收治的股外侧皮神经炎患者60例，随机分为对照组和治疗组，每组30例。对照组口服甲钴胺片，0.5 mg/次，3次/d。治疗组在对照组的基础上，穴位注射盐酸川芎嗪注射液2 mL，1次/d。两组均连续治疗30 d。观察两组的临床疗效，同时比较两组神经传导速度、疼痛缓解程度、疼痛开始缓解时间、疼痛持续时间。结果治疗后，对照组和治疗组的总显效率分别为70%、90%，两组总显效率比较差异有统计学意义（P＜0.05）。治疗后，治疗组患者疼痛缓解程度明显高于对照组，且治疗组疼痛开始缓解时间、疼痛持续时间均明显短于对照组，两组比较差异有统计学意义（P＜0.05）。治疗后两组患侧大腿神经传导速度均明显提高，同组治疗前后差异有统计学意义（P＜0.05），治疗后治疗组神经传导速度高于对照组，两组比较差异有统计学意义（P＜0.05）。结论盐酸川芎嗪联合甲钴胺治疗股外侧皮神经炎具有较好的临床疗效，可有效提高神经传导速度，改善临床症状，不良反应少，值得临床推广应用。
目的：探討鹽痠川芎嗪聯閤甲鈷胺治療股外側皮神經炎的臨床療效。方法選取2013年9月—2014年9月哈爾濱理工大學校醫院收治的股外側皮神經炎患者60例，隨機分為對照組和治療組，每組30例。對照組口服甲鈷胺片，0.5 mg/次，3次/d。治療組在對照組的基礎上，穴位註射鹽痠川芎嗪註射液2 mL，1次/d。兩組均連續治療30 d。觀察兩組的臨床療效，同時比較兩組神經傳導速度、疼痛緩解程度、疼痛開始緩解時間、疼痛持續時間。結果治療後，對照組和治療組的總顯效率分彆為70%、90%，兩組總顯效率比較差異有統計學意義（P＜0.05）。治療後，治療組患者疼痛緩解程度明顯高于對照組，且治療組疼痛開始緩解時間、疼痛持續時間均明顯短于對照組，兩組比較差異有統計學意義（P＜0.05）。治療後兩組患側大腿神經傳導速度均明顯提高，同組治療前後差異有統計學意義（P＜0.05），治療後治療組神經傳導速度高于對照組，兩組比較差異有統計學意義（P＜0.05）。結論鹽痠川芎嗪聯閤甲鈷胺治療股外側皮神經炎具有較好的臨床療效，可有效提高神經傳導速度，改善臨床癥狀，不良反應少，值得臨床推廣應用。
목적：탐토염산천궁진연합갑고알치료고외측피신경염적림상료효。방법선취2013년9월—2014년9월합이빈리공대학교의원수치적고외측피신경염환자60례，수궤분위대조조화치료조，매조30례。대조조구복갑고알편，0.5 mg/차，3차/d。치료조재대조조적기출상，혈위주사염산천궁진주사액2 mL，1차/d。량조균련속치료30 d。관찰량조적림상료효，동시비교량조신경전도속도、동통완해정도、동통개시완해시간、동통지속시간。결과치료후，대조조화치료조적총현효솔분별위70%、90%，량조총현효솔비교차이유통계학의의（P＜0.05）。치료후，치료조환자동통완해정도명현고우대조조，차치료조동통개시완해시간、동통지속시간균명현단우대조조，량조비교차이유통계학의의（P＜0.05）。치료후량조환측대퇴신경전도속도균명현제고，동조치료전후차이유통계학의의（P＜0.05），치료후치료조신경전도속도고우대조조，량조비교차이유통계학의의（P＜0.05）。결론염산천궁진연합갑고알치료고외측피신경염구유교호적림상료효，가유효제고신경전도속도，개선림상증상，불량반응소，치득림상추엄응용。
Objective To observe the clinical efficacy of ligustrazine hydrochloride combined with mecobalamin in treatment of lateral femoral cutaneous neuritis.Methods Patients (60 cases) with lateral femoral cutaneous neuritis in the School Hospital of Harbin University of Science and Technology from September 2013 to September 2014 were randomly divided into control and treatment groups, and each group had 30 cases. The patients in the control group werepo administered with Mecobalamin Tablets, 0.5 mg/time, three times daily. The patients in the treatment group were given acupoint injection 2 mL of Ligustrazine Hydrochloride Injection, once daily, and other treatment was the same as the control group. Two groups were treated for 30 d. After treatment, the efficacy was evaluated, and nerve conduction velocity, degree of pain relief, and time of pain began to ease, pain duration time in two groups were compared.ResultsThe significant efficacies in the control and treatment groups were 70% and 90%, respectively, and there were differences between two groups (P< 0.05). After treatment, the degree of pain relief in the treatment group was significantly higher than that in control group, while time of pain began to ease, pain duration time in the treatment group were shorter than those in the control group, and there were differences between two groups (P< 0.05). After treatment, the lateral thigh nerve conduction velocity in two groups was significantly improved, and the difference was statistically significant in the same group (P < 0.05). The nerve conduction velocity in treatment group was higher than that in the control group, and there were differences between two groups (P< 0.05).ConclusionLigustrazine hydrochloride combined with mecobalamin has the good clinical effect in treatment of lateral femoral cutaneous neuritis, and can effectively increase the ipsilateral nerve conduction velocity, while can improve the clinical symptoms with no adverse reaction, which is worth clinical promotion.
