现代药物与临床
現代藥物與臨床
현대약물여림상
Drugs & Clinic
2015年
4期
470-474
,共5页
2型糖尿病脑病%神经炎症%小胶质细胞%外周细胞因子%晚期糖基化终产物(AGEs)%β淀粉样肽(Aβ)
2型糖尿病腦病%神經炎癥%小膠質細胞%外週細胞因子%晚期糖基化終產物(AGEs)%β澱粉樣肽(Aβ)
2형당뇨병뇌병%신경염증%소효질세포%외주세포인자%만기당기화종산물(AGEs)%β정분양태(Aβ)
type 2 diabetic encephalopathy%neuroinflammation%microglia%periphery cytokine%advanced glycation end products (AGEs)%β amyloid peptide (Aβ)
2型糖尿病患病人数呈现快速增加的趋势，由其引发的认知功能障碍成为被关注的热点，但其发病机制尚不完全清楚。近年来一种2型糖尿病的“炎症学说”逐渐被越来越多的学者所提及，并且越来越多的研究发现某些因素能够介导神经炎症从而引发2型糖尿病脑病，将从小胶质细胞活化、外周细胞因子、晚期糖基化终产物（AGEs）与β淀粉样肽（Aβ）等方面对2型糖尿病脑病的引发进行综述，为其治疗药物的开发提供参考。
2型糖尿病患病人數呈現快速增加的趨勢，由其引髮的認知功能障礙成為被關註的熱點，但其髮病機製尚不完全清楚。近年來一種2型糖尿病的“炎癥學說”逐漸被越來越多的學者所提及，併且越來越多的研究髮現某些因素能夠介導神經炎癥從而引髮2型糖尿病腦病，將從小膠質細胞活化、外週細胞因子、晚期糖基化終產物（AGEs）與β澱粉樣肽（Aβ）等方麵對2型糖尿病腦病的引髮進行綜述，為其治療藥物的開髮提供參攷。
2형당뇨병환병인수정현쾌속증가적추세，유기인발적인지공능장애성위피관주적열점，단기발병궤제상불완전청초。근년래일충2형당뇨병적“염증학설”축점피월래월다적학자소제급，병차월래월다적연구발현모사인소능구개도신경염증종이인발2형당뇨병뇌병，장종소효질세포활화、외주세포인자、만기당기화종산물（AGEs）여β정분양태（Aβ）등방면대2형당뇨병뇌병적인발진행종술，위기치료약물적개발제공삼고。
The number of patients with type 2 diabetes mellitus (T2DM) shows a rapid increasing trend, and the cognitive dysfunction which is caused by T2DM has been a hot spot of attention, but its pathogenesis are still not entirely clear. In recent years, “the inflammation hypothesis of T2DM” has been mentioned by many researchers, and more and more researches had found that neuroinflammation could act as a trigger for type 2 diabetic encephalopathy (T2DE) which could be mediated by some factors. This review summarizes the factors which could mediate neuroinflammation causing T2DE, including the activation of microglial cells, periphery cytokines, advanced glycation end products (AGEs),β amyloid peptide, and so on, in order to provide reference for the development of treatment drugs.
