CAJ | 학술논문

目的：观察早期使用依达拉奉治疗急性缺血性脑卒中的疗效及安全性。方法将108例急性缺血性脑卒中患者随机分成治疗组(n=54)和对照组(n=54)，对照组给予常规治疗，治疗组在常规治疗基础上，治疗组给予依达拉奉治疗，对比两组患者治疗前后卒中量表评分(NIHSS)、改良Rankin量表评分(mRS)，并随访治疗后3个月的mRS评分。结果两组患者治疗第14天的NIHSS评分和mRS评分均较治疗前显著降低(P<0.05)，且治疗组降低幅度大于对照组，差异有统计学意义(P<0.05)，治疗后第90天治疗组的mRS评分显著低于对照组(P<0.05)，两组不良反应比较，差异无统计学意义(P>0.05)。结论早期使用依达拉奉治疗急性缺血性脑卒中安全、有效，值得临床推广使用。
목적：관찰조기사용의체랍봉치료급성결혈성뇌졸중적료효급안전성。방법장108례급성결혈성뇌졸중환자수궤분성치료조(n=54)화대조조(n=54)，대조조급여상규치료，치료조재상규치료기출상，치료조급여의체랍봉치료，대비량조환자치료전후졸중량표평분(NIHSS)、개량Rankin량표평분(mRS)，병수방치료후3개월적mRS평분。결과량조환자치료제14천적NIHSS평분화mRS평분균교치료전현저강저(P<0.05)，차치료조강저폭도대우대조조，차이유통계학의의(P<0.05)，치료후제90천치료조적mRS평분현저저우대조조(P<0.05)，량조불량반응비교，차이무통계학의의(P>0.05)。결론조기사용의체랍봉치료급성결혈성뇌졸중안전、유효，치득림상추엄사용。
Objective To observe the curative effect and safety of early edaravone applied in the treatment of acute ischemic stroke.Methods A total of 108 patients with acute ischemic stroke were randomly divided into treatment group (n=54) and control group (n=54). The control group received conventional treatment, and the treatment group received additional edaravone for treatment. Comparisons were made on national institutes of health stroke scale (NIHSS), modified Rankin scale (mRS), and mRS after 3-month follow-up.Results Both groups had significantly decreased NIHSS and mRS scores in 14 d of treatment, comparing with those before treatment (P<0.05). Decreased levels in the treatment group were higher than those in the control group, and their difference had statistical significance (P<0.05). In 90 d after treatment, the treatment group had much lower mRS score than the control group (P<0.05), while the difference of adverse reactions between the two groups had no statistical significance (P>0.05).Conclusion Early application of edaravone is safe and effective in treating acute ischemic stroke, and this method is worth clinical promotion and application.