中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2015年
2期
109-113
,共5页
丛斌斌%邱鹏飞%杨国仁%刘雁冰%赵桐%陈鹏%曹晓珊%王春建%张朝蓬%孙晓%王永胜
叢斌斌%邱鵬飛%楊國仁%劉雁冰%趙桐%陳鵬%曹曉珊%王春建%張朝蓬%孫曉%王永勝
총빈빈%구붕비%양국인%류안빙%조동%진붕%조효산%왕춘건%장조봉%손효%왕영성
乳腺癌%内乳区%前哨淋巴结活检%显像率
乳腺癌%內乳區%前哨淋巴結活檢%顯像率
유선암%내유구%전초림파결활검%현상솔
Breast Cancer%Internal Mammary%Sentinel Lymph Node Biopsy%Visualization rate
目的：验证乳腺癌内乳前哨淋巴结活检（ internal mammary-SLNB，IM-SLNB）中新型示踪技术的准确性。方法按新型示踪技术注射核素示踪剂，将荧光示踪剂注射于瘤周腺体内。术前淋巴闪烁显像和γ探测仪检测放射性活性的内乳前哨淋巴结（internal mammary sentinel lymph node，IM-SLN），术中对其进行前哨淋巴结活检（sentinel lymph node biopsy，SLNB），荧光示踪剂的显像情况由荧光显像系统来确定。结果自2013年9月至2014年12月共计162例入组，其中110例成功行IM-SLN，94例确定核素示踪剂和荧光示踪剂定位于同一IM-SLN，2种示踪剂的相关性和吻合度有统计学意义（ Case-base，rs ＝0.808，P＜0.001；Kappa＝0.79， P＜0.001）。结论注射于乳腺腺体内不同部位的示踪剂能引流至同一IM-SLN，证实了新型示踪技术及乳腺癌IM-SLN假说的准确性，即IM-SLN不仅接受来自原发肿瘤区域的淋巴引流且接受来自整个乳腺腺体的淋巴引流。
目的：驗證乳腺癌內乳前哨淋巴結活檢（ internal mammary-SLNB，IM-SLNB）中新型示蹤技術的準確性。方法按新型示蹤技術註射覈素示蹤劑，將熒光示蹤劑註射于瘤週腺體內。術前淋巴閃爍顯像和γ探測儀檢測放射性活性的內乳前哨淋巴結（internal mammary sentinel lymph node，IM-SLN），術中對其進行前哨淋巴結活檢（sentinel lymph node biopsy，SLNB），熒光示蹤劑的顯像情況由熒光顯像繫統來確定。結果自2013年9月至2014年12月共計162例入組，其中110例成功行IM-SLN，94例確定覈素示蹤劑和熒光示蹤劑定位于同一IM-SLN，2種示蹤劑的相關性和吻閤度有統計學意義（ Case-base，rs ＝0.808，P＜0.001；Kappa＝0.79， P＜0.001）。結論註射于乳腺腺體內不同部位的示蹤劑能引流至同一IM-SLN，證實瞭新型示蹤技術及乳腺癌IM-SLN假說的準確性，即IM-SLN不僅接受來自原髮腫瘤區域的淋巴引流且接受來自整箇乳腺腺體的淋巴引流。
목적：험증유선암내유전초림파결활검（ internal mammary-SLNB，IM-SLNB）중신형시종기술적준학성。방법안신형시종기술주사핵소시종제，장형광시종제주사우류주선체내。술전림파섬삭현상화γ탐측의검측방사성활성적내유전초림파결（internal mammary sentinel lymph node，IM-SLN），술중대기진행전초림파결활검（sentinel lymph node biopsy，SLNB），형광시종제적현상정황유형광현상계통래학정。결과자2013년9월지2014년12월공계162례입조，기중110례성공행IM-SLN，94례학정핵소시종제화형광시종제정위우동일IM-SLN，2충시종제적상관성화문합도유통계학의의（ Case-base，rs ＝0.808，P＜0.001；Kappa＝0.79， P＜0.001）。결론주사우유선선체내불동부위적시종제능인류지동일IM-SLN，증실료신형시종기술급유선암IM-SLN가설적준학성，즉IM-SLN불부접수래자원발종류구역적림파인류차접수래자정개유선선체적림파인류。
Objective To verify the accuracy of the modified technique for internal mammary sentinel lymph node biopsy ( IM-SLNB) in breast cancer .Methods In the validation study , the radiotracer was injected with the modified technique , and fluorescence tracer was injected into the peritumoral breast tissue .The radioac-tive IM-SLN was identified by preoperative lymphoscintigraphy and γprobe.The radioactive IM-SLN received bi-opsy during operation .The status of the fluorescence tracer was identified by the fluorescence imaging system . Results A total of 162 patients were enrolled from Sep .2013 to Dec.2014.IM-SLNB was performed in 110 pa-tients.The radiotracer and the fluorescence tracer were identified in the same IM-SLN in 94 cases, and the con-cordance rate was 85.5%(Case-base, Spearman coefficient correlation 0.823, P<0.001).Conclusion Dif-ferent tracers injected into the different sites of the intra-parenchyma can reach the same IM-SLN, proving the ac-curacy of the modified technique and the hypothesis of IM-SLN lymphatic drainage pattern ( IM-SLN receives not only the lymphatic drainage from the primary tumor area but the entire breast parenchyma ) .
