CAJ | 학술논문

磷丙泊酚（fospropofol）为丙泊酚的前药，在体内经碱性磷酸酶水解后释放出丙泊酚，释放出来的丙泊酚具有独特的药理性质。安全性与有效性临床试验表明，该药的镇静作用与剂量成正比。磷丙泊酚使用剂量为6.5和8 mg/kg，用于结肠镜检、支气管镜检等内镜检查时镇静，疗效、安全性和耐受性都比较好；使用6.5 mg/kg剂量作为咪达唑仑的替代品用于口腔小手术时既镇静、安全且患者易于耐受。另外，磷丙泊酚用于老年患者支气管纤维镜检，不仅安全有效且患者苏醒快、满意度高，效果与年轻患者相似；采用静脉滴注/推注方式用于ICU患者短期麻醉诱导和镇静作用的维持，耐受性和有效性均可，也可以作为全身麻醉药用于行冠状动脉旁路移植手术患者。
린병박분（fospropofol）위병박분적전약，재체내경감성린산매수해후석방출병박분，석방출래적병박분구유독특적약이성질。안전성여유효성림상시험표명，해약적진정작용여제량성정비。린병박분사용제량위6.5화8 mg/kg，용우결장경검、지기관경검등내경검사시진정，료효、안전성화내수성도비교호；사용6.5 mg/kg제량작위미체서륜적체대품용우구강소수술시기진정、안전차환자역우내수。령외，린병박분용우노년환자지기관섬유경검，불부안전유효차환자소성쾌、만의도고，효과여년경환자상사；채용정맥적주/추주방식용우ICU환자단기마취유도화진정작용적유지，내수성화유효성균가，야가이작위전신마취약용우행관상동맥방로이식수술환자。
Fospropofol is a prodrug of propofol which hydrolyzes in the body by alkaline phosphatase to liberate propofol. Propofol liberated from fospropofol has unique pharmacological properties. Fospropofol in doses of 6.5 or 8 mg/kg, is effective and well tolerated for the sedation of patients undergoing colonoscopy,flexible bronchoscopy. When administered intravenously by a dentist anesthesiologist at the indicated dose, it appearsed to be a safe, well-tolerated alternative to midazolam for intravenous moderate sedation during minor oral surgery procedures. In addition, fospropofol provides safe and effective sedation, rapid time to full alert, and high satisfaction in the elderly subset undergoing flexible bronchoscopy, which is comparable with outcomes in younger patients. Study suggested that fospropofol, administered in an infusion/bolus regimen, be tolerable and effective for short-term induction and maintenance of sedation in intensive care unit patients. Fospropofol also could be used to provide general anesthesia in patients undergoing coronary artery bypass graft surgery.