CAJ | 학술논문

芡实属于睡莲科植物，其种仁、种皮、叶柄和花梗均可入药。可通过浸提、回流和超声法提取，采用大孔树脂纯化，并利用近红外指纹图谱法、高效液相色谱法、X线衍射傅立叶分析法和ITS2条形码序列测序技术进行质量控制。芡实富含氨基酸、脂肪酸和多种微量元素，其主要药用成分包括多酚、倍半新木脂素、生育酚、脑苷脂和环二肽，具有抗氧化、清除自由基、降血糖、抗心肌缺血、降低尿蛋白、抑菌和防治胃黏膜损伤等药理活性，临床已开展芡实制剂对于糖尿病和慢性肾炎的治疗。本文综述了近年来芡实药用部位、提取纯化方式、质量控制、化学成分、药理作用及临床应用等方面的研究进展，旨在为芡实后续深入研究和开发提供参考依据。
검실속우수련과식물，기충인、충피、협병화화경균가입약。가통과침제、회류화초성법제취，채용대공수지순화，병이용근홍외지문도보법、고효액상색보법、X선연사부립협분석법화ITS2조형마서렬측서기술진행질량공제。검실부함안기산、지방산화다충미량원소，기주요약용성분포괄다분、배반신목지소、생육분、뇌감지화배이태，구유항양화、청제자유기、강혈당、항심기결혈、강저뇨단백、억균화방치위점막손상등약리활성，림상이개전검실제제대우당뇨병화만성신염적치료。본문종술료근년래검실약용부위、제취순화방식、질량공제、화학성분、약리작용급림상응용등방면적연구진전，지재위검실후속심입연구화개발제공삼고의거。
The seed, coat, petiole and peduncle of Euryale ferox(belonging to Nymphaeaceae) are used as medicinal potions through solvent extraction, reflux extraction and ultrasonic extraction, and purification on macroporous resin. The quality controls are performed by near infra-red fingerprint spectrum, HPLC, X-ray diffraction Fourier spectrum, and ITS2 barcode. The nutrients of E. ferox contain large amount of amino acids, fatty acids and various microelements; medicinal ingredients are identified to be polyphenol, sesquineolignan, tocopherol, cerebroside, and cyclic dipeptide. The pharmacological effects of E. ferox extracts include antioxidant, free radical scavenging, hypoglycemic activity, decreasing urine protein, bacteriostasis and prevention of gastric mucosal injury. Treatment with E. ferox preparations for diabetes and chronic nephritis are performed in clinics. This review summarizes the study of E. ferox in recent years for further research and development.