CAJ | 학술논문

目的：探讨三阴性乳腺癌组织中的E￣钙黏蛋白( E￣cadherin，E￣cad)的表达及其与临床病理指标和预后的关系。方法2002年1月—2008年10月在汕头大学医学院附属肿瘤医院接受治疗的女性三阴性乳腺癌组织35例，采用免疫组织化学GTvision两步法检测样本中E￣cad的表达，采用卡方检验分析其与临床病理特征的关系，应用Kaplan￣Meier法和Cox比例风险回归模型分析E￣cad表达对预后的影响。结果 E￣cad主要定位在细胞膜，35例三阴性乳腺癌组织中E￣cad的低表达率为51?4％(18/35)，其表达与临床肿瘤分期( P＝0?009)和淋巴结转移有关( P＝0?044)。 E￣cad低表达和高表达患者总体生存曲线差异有统计学意义( Log￣rank检验，P＝0?014)。 Cox比例风险回归模型分析示E￣cad是三阴性乳腺癌患者独立的预后因素(风险比0?241，95％置信区间0?072~0?814，P＝0?022)。结论 E￣cad低表达或缺失更容易引起三阴性乳腺癌的浸润转移，在三阴性乳腺癌的发展过程中起着重要作用，可以作为三阴性乳腺癌患者预后的一个重要的独立预测因素。
목적：탐토삼음성유선암조직중적E￣개점단백( E￣cadherin，E￣cad)적표체급기여림상병리지표화예후적관계。방법2002년1월—2008년10월재산두대학의학원부속종류의원접수치료적녀성삼음성유선암조직35례，채용면역조직화학GTvision량보법검측양본중E￣cad적표체，채용잡방검험분석기여림상병리특정적관계，응용Kaplan￣Meier법화Cox비례풍험회귀모형분석E￣cad표체대예후적영향。결과 E￣cad주요정위재세포막，35례삼음성유선암조직중E￣cad적저표체솔위51?4％(18/35)，기표체여림상종류분기( P＝0?009)화림파결전이유관( P＝0?044)。 E￣cad저표체화고표체환자총체생존곡선차이유통계학의의( Log￣rank검험，P＝0?014)。 Cox비례풍험회귀모형분석시E￣cad시삼음성유선암환자독립적예후인소(풍험비0?241，95％치신구간0?072~0?814，P＝0?022)。결론 E￣cad저표체혹결실경용역인기삼음성유선암적침윤전이，재삼음성유선암적발전과정중기착중요작용，가이작위삼음성유선암환자예후적일개중요적독립예측인소。
Objective To study the protein expression of E￣cadherin ( E￣cad) to understand its relationship with clinicopathological parameters and its influence on the prognosis of human triple negative breast carcinoma ( TNBC) . Methods We collected tumor tissues from 35 female patients with TNBC treated at the Cancer Hospital of Shantou University Medical College from January 2002 to October 2008. Immunohistochemistry was performed to detect the protein expression of E￣cad in breast tumors,and the chi￣square test was used to study the relationship between the E￣cad expre￣ssion and clinicopathological parameters. The Kaplan￣Meier method and Cox regression model were conducted to study the influence of E￣cad on the prognosis of TNBC. Results E￣cad protein was ex￣pressed primarily in the cytomembrane. The low expression rate of E￣cad in 35 TNBC tumors was 51?4% (18/35). The chi￣square test revealed that the E￣cad expression was related to TNM stage ( P=0?009) and lymph node metastasis ( P=0?044) . The survival curves between the low protein isoaspartyl methyltransferase expression group and the high protein isoaspartyl methyltransferase ex￣pression group were significantly different ( Log￣rank P=0?014) . Cox regression model demonstrated that E￣cad ( hazard ratio 0?241,95% confidence interval 0?072—0?814,P=0?022) was the inde￣pendent prognostic factors for TNBC. Conclusion E￣cad plays an important role in the progression of breast cancer and could be a novel prognostic factor for TNBC.