国际药学研究杂志
國際藥學研究雜誌
국제약학연구잡지
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH
2015年
2期
131-134,142
,共5页
凝血因子%重组技术%分子结构%翻译后修饰
凝血因子%重組技術%分子結構%翻譯後脩飾
응혈인자%중조기술%분자결구%번역후수식
coagulation factor%recombinant technology%molecular structure%post-translational modification
重组凝血因子面世以来,在凝血因子缺陷和相关适应证患者中达到了良好的防治效果,已经开始替代血源凝血因子制品。然而,重组制品在免疫原性和抑制物产生方面的不足也受到关注。本文对几种主要的重组凝血因子与血源凝血因子的结构差异进行了综述,包括分子序列和翻译后修饰的多种形式等,并探讨这些结构上的差异对药理学、药效学和药代动力学的可能影响。这些分子差异和机制的揭示有助于探索和改进重组凝血因子的产量和质量,具有积极的临床治疗意义。
重組凝血因子麵世以來,在凝血因子缺陷和相關適應證患者中達到瞭良好的防治效果,已經開始替代血源凝血因子製品。然而,重組製品在免疫原性和抑製物產生方麵的不足也受到關註。本文對幾種主要的重組凝血因子與血源凝血因子的結構差異進行瞭綜述,包括分子序列和翻譯後脩飾的多種形式等,併探討這些結構上的差異對藥理學、藥效學和藥代動力學的可能影響。這些分子差異和機製的揭示有助于探索和改進重組凝血因子的產量和質量,具有積極的臨床治療意義。
중조응혈인자면세이래,재응혈인자결함화상관괄응증환자중체도료량호적방치효과,이경개시체대혈원응혈인자제품。연이,중조제품재면역원성화억제물산생방면적불족야수도관주。본문대궤충주요적중조응혈인자여혈원응혈인자적결구차이진행료종술,포괄분자서렬화번역후수식적다충형식등,병탐토저사결구상적차이대약이학、약효학화약대동역학적가능영향。저사분자차이화궤제적게시유조우탐색화개진중조응혈인자적산량화질량,구유적겁적림상치료의의。
Since their successful launch, the recombinant coagulation factors have been effective in the treatment and prophylaxis of respective deficiencies, and started to replace plasma-derived coagulation factors. However, immunogenicity and induction of inhibitors associated with the uses of these recombinant products have drawn certain attention. This manuscript reviews the structural differences between several major recombinant coagulation factors and their plasma-derived counterparts, including sequences and many forms of post-translational modifications, and discusses the possible effects of these structural differences on the pharmacology, efficacy and pharmacokinetics of the products. The demonstration of structural differences and underlying mechanisms helps to improve the production yield and quality of recombinant coagulation factors, which is of significant clinical importance.