中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
14期
21-22
,共2页
头孢孟多酯钠%奥美拉唑钠%配伍禁忌
頭孢孟多酯鈉%奧美拉唑鈉%配伍禁忌
두포맹다지납%오미랍서납%배오금기
Cefamandole nafate%Omeprazole sodium%Incompatibility
目的：探讨注射用头孢孟多酯钠与注射用奥美拉唑钠的配伍禁忌。方法高效液相色谱法(HPLC)法测定头孢孟多酯钠、奥美拉唑钠配伍液在4、25、30℃环境下放置6 h内不同时间点外观、相对含量及pH值的变化。结果在室温(25、30℃)条件6 h下，配伍液外观、澄明度及pH值发生明显变化，且头孢孟多酯钠、奥美拉唑钠含量明显降低。结论注射用头孢孟多酯钠与注射用奥美拉唑钠存在配伍禁忌，应间隔使用。
目的：探討註射用頭孢孟多酯鈉與註射用奧美拉唑鈉的配伍禁忌。方法高效液相色譜法(HPLC)法測定頭孢孟多酯鈉、奧美拉唑鈉配伍液在4、25、30℃環境下放置6 h內不同時間點外觀、相對含量及pH值的變化。結果在室溫(25、30℃)條件6 h下，配伍液外觀、澄明度及pH值髮生明顯變化，且頭孢孟多酯鈉、奧美拉唑鈉含量明顯降低。結論註射用頭孢孟多酯鈉與註射用奧美拉唑鈉存在配伍禁忌，應間隔使用。
목적：탐토주사용두포맹다지납여주사용오미랍서납적배오금기。방법고효액상색보법(HPLC)법측정두포맹다지납、오미랍서납배오액재4、25、30℃배경하방치6 h내불동시간점외관、상대함량급pH치적변화。결과재실온(25、30℃)조건6 h하，배오액외관、징명도급pH치발생명현변화，차두포맹다지납、오미랍서납함량명현강저。결론주사용두포맹다지납여주사용오미랍서납존재배오금기，응간격사용。
Objective To investigate the incompatibility between cefamandole nafate for injection and omeprazole sodium for injection.Methods High performance liquid chromatography (HPLC) was applied to detect changes of external appearance, relative amount and pH of cefamandole nafate and omeprazole sodium in different time points during 6 h under 4, 25, and 30℃.Results After 6 h under indoor temperature (25 and 30℃), the solutions had obvious changes in external appearance, clarity, and pH. Contents of cefamandole nafate and omeprazole sodium were remarkably decreased.Conclusion Cefamandole nafate for injection is incompatible with omeprazole sodium for injection, and they should be applied separately.
