CAJ | 학술논문

目的：探讨血清可溶性髓样细胞触发受体‐1（sTREM‐1）对脓毒血症的早期诊断价值。方法选择2010年7月至2013年6月该院急诊重症病房重症监护病房收治的81例患者，其中61例全身炎症反应综合征（SIRS ）患者，根据脓毒血症诊断标准分为脓毒血症组39例与SIRS组22例，非SIRS患者20例作为对照组，检测3组血清sTREM‐1和降钙素原（PCT）水平。结果脓毒血症组与SIRS组血清sTREM‐1及PCT水平均明显高于对照组（P＜0．01）；脓毒血症组血清sTREM‐1及PCT水平均明显高于SIRS组（P＜0．01）；sTREM‐1和PCT在SIRS患者中早期诊断脓毒血症的受试者工作特征曲线下面积分别为0．932和0．670，sTREM‐1的灵敏度和特异度分别为92．3％和86．4％，PCT 的灵敏度和特异度分别为61．5％和81．8％。结论血清sTREM‐1是脓毒血症早期诊断的较好指标，同时具有较高的灵敏度和特异度，优于PCT。
목적：탐토혈청가용성수양세포촉발수체‐1（sTREM‐1）대농독혈증적조기진단개치。방법선택2010년7월지2013년6월해원급진중증병방중증감호병방수치적81례환자，기중61례전신염증반응종합정（SIRS ）환자，근거농독혈증진단표준분위농독혈증조39례여SIRS조22례，비SIRS환자20례작위대조조，검측3조혈청sTREM‐1화강개소원（PCT）수평。결과농독혈증조여SIRS조혈청sTREM‐1급PCT수평균명현고우대조조（P＜0．01）；농독혈증조혈청sTREM‐1급PCT수평균명현고우SIRS조（P＜0．01）；sTREM‐1화PCT재SIRS환자중조기진단농독혈증적수시자공작특정곡선하면적분별위0．932화0．670，sTREM‐1적령민도화특이도분별위92．3％화86．4％，PCT 적령민도화특이도분별위61．5％화81．8％。결론혈청sTREM‐1시농독혈증조기진단적교호지표，동시구유교고적령민도화특이도，우우PCT。
Objective To investigate the early diagnostic value of soluble triggering receptor expressed on myeloid cells‐1 (sTREM‐1) in patients with sepsis .Methods Eighty‐one patients between July 2010 and June 2013 were collected .Sixty one pa‐tients with systemic inflammatory response syndrome (SIRS) were divided into sepsis group (n=39) and SIRS group (n=22) ,and the other 20 patients without SIRS were as control group .Levels of sTREM‐1 and procalcitonin (PCT ) were measured .Results The levels of sTREM‐1 and PCT were significant higher in sepsis group and SIRS group than those in control group (P<0 .01) , and the levels of sTREM‐1 and PCT in sepsis group were significant higher than those in SIRS group (P<0 .01) .The area under the curve (AUC) of sTREM‐1 and PCT were 0 .932 and 0 .670 ,respectively .The sensibility and specificity of sTREM‐1 were 92 .3% and 86 .4% ,while the sensibility and specificity of PCT were 61 .5% and 81 .8% .Conclusion Serum sTREM‐1 might be a good biomarker for the early diagnosis of sepsis ,and it has higher sensitivity and specificity in compassion with PCT .