CAJ | 학술논문

Wnt信号传导通路是一个由多种分子参与、相互影响、相互制约和协同作用的复杂体系，与细胞信号转导、细胞周期、细胞增殖、细胞凋亡、细胞黏附和迁移以及干细胞的分化潜能等有关。泛素蛋白酶体系统通过调控蛋白活性、亚细胞定位以及蛋白间相互作用等方式在细胞活动中发挥重要的作用。 Wnt信号传导通路中β-catenin等关键分子受泛素蛋白酶体途径精密调控。本文就泛素蛋白酶体系统和Wnt通路信号传导相互之间的关系作一综述。
Wnt신호전도통로시일개유다충분자삼여、상호영향、상호제약화협동작용적복잡체계，여세포신호전도、세포주기、세포증식、세포조망、세포점부화천이이급간세포적분화잠능등유관。범소단백매체계통통과조공단백활성、아세포정위이급단백간상호작용등방식재세포활동중발휘중요적작용。 Wnt신호전도통로중β-catenin등관건분자수범소단백매체도경정밀조공。본문취범소단백매체계통화Wnt통로신호전도상호지간적관계작일종술。
Wnt signal pathway is a complex system involved by a variety of molecular which are influenced,restricted and syn-ergied by each other. It is related with the cell signal transduction,cell cycle,cell proliferation,migration and differentiation,apoptosis, adhesion and the potential differentiation ability of stem cells. Ubiquitin proteasome system plays an important role in cell activity through regulated the protein activity,subcellular localization,protein interaction,et al. The key moleculars in Wnt signal pathway,such as β-catenin,is closely regulated by ubiquitin proteasome system. The purpose of this paper is to elaborate the relationship of the Wnt signal pathway with the ubiquitin proteasome system.