CAJ | 학술논문

目的：探讨肺炎衣原体（Cpn）血清学检测在急性冠状动脉综合征（ACS）患者中的应用效果。方法采用聚合酶链反应（PCR）对2012年10月至2013年10月在该院诊治的ACS患者（冠脉组）和健康体检者（对照组）各80例进行Cpn DNA检测，根据检测结果，将ACS患者分为衣原体组和非衣原体组。同时进行血清肿瘤坏死因子α（TNF‐α）、C反应蛋白（CRP）、细胞间黏附分子1（ICAM‐1）、血脂水平检测，分析肺炎衣原体感染与ACS的关系。结果冠脉组Cpn阳性53例、阴性27例，对照组Cpn阳性7例、阴性83例，比较差异有统计学意义（P＜0．05）。ACS患者中，衣原体组血清 TNF‐α、CRP、ICAM‐1、总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平均高于非衣原体组（P＜0．05）；而高密度脂蛋白胆固醇水平则低于非衣原体组（P＜0．05）。结论 Cpn感染与ACS具有一定的相关性。Cpn感染通过提高ACS患者炎性因子水平参与疾病发展，并使患者继发高血脂症。
목적：탐토폐염의원체（Cpn）혈청학검측재급성관상동맥종합정（ACS）환자중적응용효과。방법채용취합매련반응（PCR）대2012년10월지2013년10월재해원진치적ACS환자（관맥조）화건강체검자（대조조）각80례진행Cpn DNA검측，근거검측결과，장ACS환자분위의원체조화비의원체조。동시진행혈청종류배사인자α（TNF‐α）、C반응단백（CRP）、세포간점부분자1（ICAM‐1）、혈지수평검측，분석폐염의원체감염여ACS적관계。결과관맥조Cpn양성53례、음성27례，대조조Cpn양성7례、음성83례，비교차이유통계학의의（P＜0．05）。ACS환자중，의원체조혈청 TNF‐α、CRP、ICAM‐1、총담고순、삼선감유、저밀도지단백담고순수평균고우비의원체조（P＜0．05）；이고밀도지단백담고순수평칙저우비의원체조（P＜0．05）。결론 Cpn감염여ACS구유일정적상관성。Cpn감염통과제고ACS환자염성인자수평삼여질병발전，병사환자계발고혈지증。
Objective To evaluate the application of serological detection of Chlamydia pneumonia (Cpn) in patients with acute coronary syndrome (ACS) .Methods From Oct .2012 to Oct .2013 ,80 patients with ACS (ACS group) and 80 healthy subjects (control group) were enrolled and detected for Cpn DNA .According to the detected results ,ACS patients were divided to chlamydia group and non‐chlamydia group .Serum levels of tumor necrosis factor α(TNF‐α) ,C reaction protein (CRP) ,intercellular cell adhe‐sion molecule‐1 (ICAM‐1) and lipoprotein were also detected .Results In ACS group ,53 cases were Cpn positive and 27 cases were Cpn negative ,and in control group ,7 cases were Cpn positive and 83 cases were Cpn negative ,which were with statistical difference between the two groups (P<0 .05) .Serum levels of TNF‐α,CRP ,ICAM‐1 ,total cholesterol ,triacylglycerol and low density lipo‐protein cholesterol were higher in chlamydia group and that of high density lipoprotein cholesterol was lower than non‐chlamydia group (P<0 .05) .Conclusion Chlamydia pneumoniae infection might be correlated with ACS .Chlamydia pneumoniae infection could be involved in disease development by increasing levels of inflammatory cytokines in ACS patients ,and further improve serum lipid levels .