中华烧伤杂志
中華燒傷雜誌
중화소상잡지
16
2015年
2期
157-159
,共3页
瘢痕%真皮%胶原%核心蛋白多糖%装配
瘢痕%真皮%膠原%覈心蛋白多糖%裝配
반흔%진피%효원%핵심단백다당%장배
Cicatrix%Dermis%Collagen%Decorin%Assembly
Formation of dermal collagen fiber is a complicated and sequential process with the progressive assembly of collagen.Collagen monomers form stepped and orderly protofibrils through longitudinal displacement.Subsequently,protofibrils or protofibrils and collagen are bonded by covalent bonds to form orderly lamellar structure of collagen fibers.Then collagen fibers are tightly wound into coarse collagen fiber bundles by covalent crosslinking.Decorin is a multifunctional small leucinerich proteoglycan.It can prevent the aggregation of protofibrils by binding to the specific site of collagen with its core protein,and adjusting the spacing between the protofibrils with its glycosaminoglycan chain.Thus,by effecting the formation of collagen fibers with regulation of collagen assembly,decorin may help prevent scar formation and even promote regeneration.
