CAJ | 학술논문

目的：探讨超敏C反应蛋白（hs‐CRP）、同型半胱氨酸（Hcy）、缺血修饰清蛋白（IMA）三者联合检测对糖尿病（DM ）及其并发症的意义。方法对健康对照组、单纯糖尿病组、糖尿病合并视网膜病变（DR）组、糖尿病肾病（DN）组、糖尿病合并冠心病（CHD）组的hs‐CRP、Hcy和IMA值进行测定，统计分析各组之间三者水平的差异是否有统计学意义。结果单纯糖尿病组、DR组、DN组、CHD组hs‐CRP、Hcy、IMA水平均高于健康对照组，差异有统计学意义（ t＝4．433，P＝0．000；t＝2．930，P＝0．004；t＝4．590，P＝0．000；t＝5．328，P＝0．000。 t＝8．629，P＝0．000；t＝11．229，P＝0．000；t＝11．230，P＝ 0．000；t＝12．444，P＝ 0．000。 t＝6．271，P＝ 0．000；t＝ 5．511，P＝0．000；t＝5．950，P＝0．000；t＝12．463，P＝0．000）。三者水平均以CHD组最高。DN组及CHD组hs‐CRP、Hcy和IM A水平与单纯糖尿病组相比，差异均有统计学意义（t＝3．130，P＝0．002；t＝3．640，P＝0．000；t＝2．102，P＝0．039。 t＝2．505，P＝0．014；t＝3．598，P＝0．001；t＝2．821，P＝0．006）。DR组 Hcy和IMA水平与单纯糖尿病组相比，差异有统计学意义（t＝ 2．082，P＝ 0．041；t＝ 2．613，P＝ 0．011），两组 hs‐CRP水平差异无统计学意义（t＝1．717，P＝0．090）。单纯糖尿病组IMA与hs‐CRP和 Hcy呈正相关（r＝0．348，P＝0．000；r＝0．271，P＝0．004）；糖尿病并发症组IM A与 hs‐CRP和 Hcy也呈正相关（ r＝ 0．294，P＝0．002；r＝0．257，P＝ 0．007 ），且 hs‐CRP与Hcy呈正相关（r＝0．210，P＝0．010）。结论 hs‐CRP、Hcy、IM A与糖尿病及其并发症密切相关，三者联合检测有助于监测和控制糖尿病及并发症的发生和发展。
목적：탐토초민C반응단백（hs‐CRP）、동형반광안산（Hcy）、결혈수식청단백（IMA）삼자연합검측대당뇨병（DM ）급기병발증적의의。방법대건강대조조、단순당뇨병조、당뇨병합병시망막병변（DR）조、당뇨병신병（DN）조、당뇨병합병관심병（CHD）조적hs‐CRP、Hcy화IMA치진행측정，통계분석각조지간삼자수평적차이시부유통계학의의。결과단순당뇨병조、DR조、DN조、CHD조hs‐CRP、Hcy、IMA수평균고우건강대조조，차이유통계학의의（ t＝4．433，P＝0．000；t＝2．930，P＝0．004；t＝4．590，P＝0．000；t＝5．328，P＝0．000。 t＝8．629，P＝0．000；t＝11．229，P＝0．000；t＝11．230，P＝ 0．000；t＝12．444，P＝ 0．000。 t＝6．271，P＝ 0．000；t＝ 5．511，P＝0．000；t＝5．950，P＝0．000；t＝12．463，P＝0．000）。삼자수평균이CHD조최고。DN조급CHD조hs‐CRP、Hcy화IM A수평여단순당뇨병조상비，차이균유통계학의의（t＝3．130，P＝0．002；t＝3．640，P＝0．000；t＝2．102，P＝0．039。 t＝2．505，P＝0．014；t＝3．598，P＝0．001；t＝2．821，P＝0．006）。DR조 Hcy화IMA수평여단순당뇨병조상비，차이유통계학의의（t＝ 2．082，P＝ 0．041；t＝ 2．613，P＝ 0．011），량조 hs‐CRP수평차이무통계학의의（t＝1．717，P＝0．090）。단순당뇨병조IMA여hs‐CRP화 Hcy정정상관（r＝0．348，P＝0．000；r＝0．271，P＝0．004）；당뇨병병발증조IM A여 hs‐CRP화 Hcy야정정상관（ r＝ 0．294，P＝0．002；r＝0．257，P＝ 0．007 ），차 hs‐CRP여Hcy정정상관（r＝0．210，P＝0．010）。결론 hs‐CRP、Hcy、IM A여당뇨병급기병발증밀절상관，삼자연합검측유조우감측화공제당뇨병급병발증적발생화발전。
Objective To explore the significance of the joint detection of hypersensitive C‐reactive protein (hs‐CRP) ,homocysteine(Hcy ) and ischemia modified albumin (IM A ) in diabetes and its complications .Methods The levels of hs‐CRP ,Hcy and IMA were measured in the normal group ,diabetes mellitus(DM) group ,diabetic reti‐nopathy(DR) group ,diabetic nephropathy(DN) group ,diabetes complicating coronary heart disease(CHD) group and the differences in these indicators among various groups were statistically analyzed .Results The levels of hs‐CRP , Hcy and IMA in the DM group ,DN group ,diabetes complicating CHD group were higher than those in the control group ,the differences were statistically significant (t=4 .433 ,P=0 .000;t=2 .930 ,P=0 .004;t=4 .590 ,P=0 .000 ;t=5 .328 ,P=0 .000 .t=8 .629 ,P=0 .000 ;t=11 .229 ,P=0 .000;t=11 .230 ,P=0 .000;t=12 .444 ,P= 0 .000 .t=6 .271 ,P=0 .000;t=5 .511 ,P=0 .000 ;t=5 .950 ,P=0 .000 ;t=12 .463 ,P=0 .000) ,in which the levels of three indi‐cators were highest in the CHD group .Meanwhile ,the hs‐CRP ,Hcy and IMA levels had statistical differences be‐tween the DN group and CHD group with the DM group (t=3 .130 ,P=0 .002 ;t=3 .640 ,P=0 .000 ;t=2 .102 ,P=0 .039 .t=2 .505 ,P=0 .014 ;t= 3 .598 ,P=0 .001;t=2 .821 ,P=0 .006) .There were significant differences in Hcy and IMA levels between the DR group and DM group(t=2 .082 ,P=0 .041 ;t=2 .613 ,P=0 .011) ,while the hs‐CRP level had no statistical difference(t=1 .717 ,P=0 .090) .The IMA level in the DM group was positively correlated with the leves of hs‐CRP and Hcy (r=0 .348 ,P=0 .000 ;r=0 .271 ,P=0 .004);the levels of IMA in the DM compli‐cations groups was positively correlated with the levels of hs‐CRP and Hcy (r=0 .294 ,P= 0 .002 ;r= 0 .257 ,P=0 .007) ,moreover ,The hs‐CRP leve was positively correlated with the Hcy level (r=0 .210 ,P=0 .010) .Conclusion hs‐CRP ,Hcy and IMA have close relationships with diabetes and its complications ,the joint detection of the three in‐dicators is helpful to monitor and control the occurrence and development of diabetes and its complications .