CAJ | 학술논문

目的：比较加巴喷丁联合喹硫平与单用喹硫平治疗血管性痴呆叠加谵妄的疗效与疗效指数（CGI －EI）。方法血管性痴呆叠加谵妄患者62例，随机分成治疗组（加巴喷丁联合喹硫平组，30例）和对照组（单用喹硫平组，32例），在治疗前及治疗后3、9、15天进行谵妄量表（DSS ）评分，在治疗前和治疗后15天进行智能精神状态检查表（MMSE）、日常生活评定量表（ADL）及临床疗效总评量表（CGI）评分。结果治疗组与对照组治疗血管性痴呆叠加谵妄均有效，疗效指数增高。与对照组比较，治疗组的 DSS 评分在治疗后3、9、15天时明显增高，差异有统计学意义（P ＜0．05或 P ＜0．01）；治疗后 MMSE 评分明显增高，CGI 严重程度评分（CGI －SI）明显降低，疗效总评（CGI －GI）明显降低，CGI －EI 明显增高，差异有统计学意义（P ＜0．05）；ADL 评分的差异无统计学意义（P ＞0．05）。结论在治疗血管性痴呆叠加谵妄时，加巴喷丁联合喹硫平较单用喹硫平控制谵妄症状快，疗效和疗效指数更高，且较为安全。
목적：비교가파분정연합규류평여단용규류평치료혈관성치태첩가섬망적료효여료효지수（CGI －EI）。방법혈관성치태첩가섬망환자62례，수궤분성치료조（가파분정연합규류평조，30례）화대조조（단용규류평조，32례），재치료전급치료후3、9、15천진행섬망량표（DSS ）평분，재치료전화치료후15천진행지능정신상태검사표（MMSE）、일상생활평정량표（ADL）급림상료효총평량표（CGI）평분。결과치료조여대조조치료혈관성치태첩가섬망균유효，료효지수증고。여대조조비교，치료조적 DSS 평분재치료후3、9、15천시명현증고，차이유통계학의의（P ＜0．05혹 P ＜0．01）；치료후 MMSE 평분명현증고，CGI 엄중정도평분（CGI －SI）명현강저，료효총평（CGI －GI）명현강저，CGI －EI 명현증고，차이유통계학의의（P ＜0．05）；ADL 평분적차이무통계학의의（P ＞0．05）。결론재치료혈관성치태첩가섬망시，가파분정연합규류평교단용규류평공제섬망증상쾌，료효화료효지수경고，차교위안전。
Objective To compare the efficacy and efficacy index (CGI -EI) of delirium superimposed on vascular dementia using combined gabapentin and quetiapine and quetiapine alone.Methods A total of 62 patients with delirium superimposed on vascular dementia were randomly divided into a control group receiving quetiapine alone (n =32) and a treatment group given combined gabapentin and quetiapine (n =30).All patients underwent DSS assessment before and 3, 9, and 15 days after treatment.They were assessed according to MMSE, ADL and CGI scales before and 15 days after treatment.Results Both therapies could treat delirium superimposed on vascular dementia effectively, with high efficacy index.Compared with the control, the treatment group could result in remarkably increased DSS, MMSE and CGI -EI scores 3, 9 and 15 days after treatment (P <0.05 or P <0.01), in contrast with significantly decreased CGI -SI and CGI -GI scores (P <0.05).However, no statistical difference was seen as to ADL score between both groups (P >0.05).Conclusions Combined gabapentin and quetiapine when applied for delirium superimposed on vascular demen-tia, controls delirium related symptoms faster and produces better efficacy and higher efficacy index, which can be safely used.