国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
8期
1110-1112
,共3页
2型糖尿病%低血糖%实验室检查指标%机体损伤%糖化血红蛋白
2型糖尿病%低血糖%實驗室檢查指標%機體損傷%糖化血紅蛋白
2형당뇨병%저혈당%실험실검사지표%궤체손상%당화혈홍단백
type 2 diabetes mellitus%hypoglycemia%laboratory index%injury of body%glycosylated hemoglobin
目的：分析2型糖尿病（T2DM ）低血糖患者的实验室检查指标，研究低血糖是否会加重机体损伤，加快并发症的进展。方法选取2014年1～6月住院发生低血糖的T2DM 患者27例作为低血糖组，另选取未发生过低血糖的糖尿病住院患者80例作为非低血糖组，比较两组各项指标的差异及低血糖发生前后各指标的变化。同时研究低血糖发生率与糖化血红蛋白（HbA1c）控制程度的关系。结果低血糖组患者年龄、病程、丙氨酸氨基转移酶（ALT）、肌酐（SCr）和尿蛋白排出量（Upro）均高于非低血糖组，差异均有统计学意义（P＜0．05）；而两组间空腹血糖（FPG）、性别、体质量指数（BMI）和HbA1c比较差异无统计学意义（P＞0．05）。T2DM患者低血糖发生后肌酸激酶（CK）、超敏C反应蛋白（hs‐CRP）和纤维蛋白原（FIB）水平均高于发生前，超氧化物歧化酶（SOD）水平低于发生前，差异均有统计学意义（P＜0．05）。T2DM 患者低血糖发生率与 HbA1c呈不完全逆相关关系（P＞0．05），趋势图显示 HbA1c控制接近正常时较控制不良者发生率增高更明显。结论 T2DM 患者年龄较大和病程较长及HbA1c水平接近正常时较易发生低血糖，低血糖的发生会加重T2DM 患者的机体损伤，加快并发症的进展。
目的：分析2型糖尿病（T2DM ）低血糖患者的實驗室檢查指標，研究低血糖是否會加重機體損傷，加快併髮癥的進展。方法選取2014年1～6月住院髮生低血糖的T2DM 患者27例作為低血糖組，另選取未髮生過低血糖的糖尿病住院患者80例作為非低血糖組，比較兩組各項指標的差異及低血糖髮生前後各指標的變化。同時研究低血糖髮生率與糖化血紅蛋白（HbA1c）控製程度的關繫。結果低血糖組患者年齡、病程、丙氨痠氨基轉移酶（ALT）、肌酐（SCr）和尿蛋白排齣量（Upro）均高于非低血糖組，差異均有統計學意義（P＜0．05）；而兩組間空腹血糖（FPG）、性彆、體質量指數（BMI）和HbA1c比較差異無統計學意義（P＞0．05）。T2DM患者低血糖髮生後肌痠激酶（CK）、超敏C反應蛋白（hs‐CRP）和纖維蛋白原（FIB）水平均高于髮生前，超氧化物歧化酶（SOD）水平低于髮生前，差異均有統計學意義（P＜0．05）。T2DM 患者低血糖髮生率與 HbA1c呈不完全逆相關關繫（P＞0．05），趨勢圖顯示 HbA1c控製接近正常時較控製不良者髮生率增高更明顯。結論 T2DM 患者年齡較大和病程較長及HbA1c水平接近正常時較易髮生低血糖，低血糖的髮生會加重T2DM 患者的機體損傷，加快併髮癥的進展。
목적：분석2형당뇨병（T2DM ）저혈당환자적실험실검사지표，연구저혈당시부회가중궤체손상，가쾌병발증적진전。방법선취2014년1～6월주원발생저혈당적T2DM 환자27례작위저혈당조，령선취미발생과저혈당적당뇨병주원환자80례작위비저혈당조，비교량조각항지표적차이급저혈당발생전후각지표적변화。동시연구저혈당발생솔여당화혈홍단백（HbA1c）공제정도적관계。결과저혈당조환자년령、병정、병안산안기전이매（ALT）、기항（SCr）화뇨단백배출량（Upro）균고우비저혈당조，차이균유통계학의의（P＜0．05）；이량조간공복혈당（FPG）、성별、체질량지수（BMI）화HbA1c비교차이무통계학의의（P＞0．05）。T2DM환자저혈당발생후기산격매（CK）、초민C반응단백（hs‐CRP）화섬유단백원（FIB）수평균고우발생전，초양화물기화매（SOD）수평저우발생전，차이균유통계학의의（P＜0．05）。T2DM 환자저혈당발생솔여 HbA1c정불완전역상관관계（P＞0．05），추세도현시 HbA1c공제접근정상시교공제불량자발생솔증고경명현。결론 T2DM 환자년령교대화병정교장급HbA1c수평접근정상시교역발생저혈당，저혈당적발생회가중T2DM 환자적궤체손상，가쾌병발증적진전。
Objective To analyze the laboratory indexes related to type 2 diabetes mellitus(T2DM ) and to explore whether hy‐poglycemia would aggravate the injury of body and development of complication .Methods 27 cases of patients with T2DM from Jan .to Jun .2014 were enrolled in hypoglycemia group ,and 80 patients of diabetes mellitus without hypoglycemia were enrolled in non‐hypoglycemia group .The laboratory indexes were compared between the two groups ,and the relationship between incidence rate of hypoglycemia and levels of glycosylated hemoglobin (HbAc1) were also analyzed ..Results The age ,course of the disease , levels of alanine aminotransferase (ALT ) and serum creatinine (SCr) and urinary protein excretion (Upro ) in the hypoglycemia group were higher than those in the non‐hypoglycemia group ,there were statistical significant differences (P<0 .05);while there was no significant differences in levels of fasting plasma glucose(FPG) and HbA1c ,gender and body mass index(BMI) between the two groups(P>0 .05) .The levels of creatine kinase(CK) ,high sensitivity C‐reactive protein(hs‐CRP) and fibrinogen(FIB) in pa‐tients with T2DM after developing hypoglycemia were higher than those in patients before developing hypoglycemia ,while superox‐ide dismutase(SOD) was lower ,there were statistical significant differences (P<0 .05) .It showed an incomplete inverse correlation between risk of hypoglycemia in patients with T 2DM and levels of HbA1c(P>0 .05) ,at the same time the risk of hypoglycemia tended to be higher in patients with near‐normal level of HbA1c than patients with poor HbA1c control .Conclusion The older , long course of disease and near‐normal levels of HbA1c controled in patients with T2DM may be prone to develop hypoglycemia . Hypoglycemia could aggravate the body injury and speed up the development of complications of T 2DM .
