CAJ | 학술논문

目的：探讨脓毒症患者血小板聚集功能及P选择素、活化GPⅡb／Ⅲa等血小板活化指标的变化及其意义。方法检测56例脓毒症患者血小板聚集功能及P选择素、活化G PⅡb／Ⅲa的变化。将脓毒症患者分为器官功能不全组和器官功能正常组进行比较分析，并与50例健康对照组进行比较。结果脓毒症患者血小板聚集率显著升高，与健康对照组比较差异有统计学意义（P＜0．05），血小板表面表达的P选择素、活化GPⅡb／Ⅲa明显升高，与健康对照组比较差异有统计学意义（P＜0．05）；器官功能不全组血小板聚集率及血小板表面表达的P选择素、活化GPⅡb／Ⅲa与器官功能正常组比较显著升高，差异有统计学意义（P＜0．05）。结论脓毒症患者血小板处于高激活状态，血小板聚集率显著升高，易导致患者发生血栓，血小板聚集率及活化指标可作为判断脏器功能损害的指标之一。
목적：탐토농독증환자혈소판취집공능급P선택소、활화GPⅡb／Ⅲa등혈소판활화지표적변화급기의의。방법검측56례농독증환자혈소판취집공능급P선택소、활화G PⅡb／Ⅲa적변화。장농독증환자분위기관공능불전조화기관공능정상조진행비교분석，병여50례건강대조조진행비교。결과농독증환자혈소판취집솔현저승고，여건강대조조비교차이유통계학의의（P＜0．05），혈소판표면표체적P선택소、활화GPⅡb／Ⅲa명현승고，여건강대조조비교차이유통계학의의（P＜0．05）；기관공능불전조혈소판취집솔급혈소판표면표체적P선택소、활화GPⅡb／Ⅲa여기관공능정상조비교현저승고，차이유통계학의의（P＜0．05）。결론농독증환자혈소판처우고격활상태，혈소판취집솔현저승고，역도치환자발생혈전，혈소판취집솔급활화지표가작위판단장기공능손해적지표지일。
Objective To explore the platelet aggregation function and the change of the P selectin ,activated GPⅡb/Ⅲa in the patients with sepsis and their significance .Methods The platelet aggregation function and P selec‐tin ,activated GPⅡb/Ⅲa levels were detected in 56 cases of sepsis .The sepsis patients were divided into the organ dysfunction group and the normal organ function group for conducting the comparative analysis ,and the comparison with 50 healthy controls were performed .Results The platelet aggregation rate in sepsis patients was significantly increased ,showing the statistically significant difference compared with healthy control group(P<0 .05) ,the levels of P selectin and activated GPⅡb/Ⅲis expressed on platelet surface were significantly increased ,showing the statistical‐ly significant difference compared with healthy control group (P<0 .05);the platelet aggregation rate and the levels of P selectin and activated GPⅡb/Ⅲexpressed on platelet surface in the organ dysfunction group were significantly increased compared with the normal organ function group ,the difference was statistically significant(P<0 .05) .Con‐clusion The platelets in sepsis patients are in high activated state ,and the platelet aggregation rate is significantly in‐creased ,which is easily cause the patients to develop thrombosis .The platelet aggregation rate and activated indexes can be used as the indicators for judging visceral function damage .