CAJ | 학술논문

目的：观察同型半胱氨酸（Hcy）、一氧化氮（NO）、内皮素（ET）与冠状动脉病变严重程度的相关性。方法选取2013年1～11月入院时高度怀疑冠心病，且愿意接受冠状动脉造影（CAG）的检查者，自愿参与研究的患者。对入选患者行CAG检查，选取CAG检查正常者50例作为空白对照组（A组），CAG检查诊断为冠心病患者100例，分为单支病变组（B组）、双支病变组（C组）和三支病变组（D组），根据Gensini积分方法对冠心病患者进行积分评定，所有患者在入院第2天测量血Hcy、NO及ET。结果Hcy、ET顺序从小到大为A组、B组、C组、D组，NO顺序从大到小为A组、B组、C组、D组，各组间比较差异有统计学意义（P＜0．05）。冠心病患者Gensini积分与Hcy和ET呈正相关，与NO呈负相关（P＜0．05），但相关性较弱。结论冠心病患者Hcy、ET较空白对照组明显升高，NO则明显下降，随着冠状动脉病变程度逐渐加重，这种变化表现越显著。因此，本文认为，Hcy、ET、NO可反映冠状动脉病变的严重程度。
목적：관찰동형반광안산（Hcy）、일양화담（NO）、내피소（ET）여관상동맥병변엄중정도적상관성。방법선취2013년1～11월입원시고도부의관심병，차원의접수관상동맥조영（CAG）적검사자，자원삼여연구적환자。대입선환자행CAG검사，선취CAG검사정상자50례작위공백대조조（A조），CAG검사진단위관심병환자100례，분위단지병변조（B조）、쌍지병변조（C조）화삼지병변조（D조），근거Gensini적분방법대관심병환자진행적분평정，소유환자재입원제2천측량혈Hcy、NO급ET。결과Hcy、ET순서종소도대위A조、B조、C조、D조，NO순서종대도소위A조、B조、C조、D조，각조간비교차이유통계학의의（P＜0．05）。관심병환자Gensini적분여Hcy화ET정정상관，여NO정부상관（P＜0．05），단상관성교약。결론관심병환자Hcy、ET교공백대조조명현승고，NO칙명현하강，수착관상동맥병변정도축점가중，저충변화표현월현저。인차，본문인위，Hcy、ET、NO가반영관상동맥병변적엄중정도。
Objective To observe the correlation of homocysteine (Hcy) ,nitrogen monoxide(NO) and endo‐thelin(ET)with the severity of coronary artery lesion .Methods 150 inpatients with highly suspicious coronary heart disease(CHD) and willingly receiving coronary angiography(CAG) in our hospital from January 2013 to November 2013 were included in this research .All the patients were performed the CAG examination .Among them ,50 cases of normal CAG were selected as the blank control group(group A) and 100 cases were diagnosed as CHD by CAD and divided into the single‐vessel lesion group(group B) ,double‐vessel lesion group(group C) and three‐vessel lesion group(group D) .All CHD patients were scored according to the Gensini score method .The levels of Hcy ,NO and ET on 2 d after admission were measured in all patients .Results The sequence of Hcy and ET levels from small to large was the group A ,B ,C and D ,while the sequence of the NO level from large to small was the group A ,B ,C and D ,the differences among groups were statistically significant(P<0 .05) .In CHD patients ,the Gensini score had the positive correlation with Hcy and ET(P<0 .05)and the negative correlation with NO(P<0 .05) ,but the correlation was weak .Conclusion The levels of Hcy and ET in CHD patients are significantly increased compared with the blank control group and the NO is significantly decreased ,as the coronary lesions are gradually aggravated ,this change will be more significant .Therefore ,it is thought that Hcy ,ET and NO can reflect the severity of coronary le‐sions .