CAJ | 학술논문

目的：探讨糖化血红蛋白检测在前驱糖尿病诊断和监测的临床意义。方法对434例成都军区机关医院内分泌科门诊就诊者进行空腹血糖、餐后2h血糖和糖化血红蛋白测定，并对其结果进行统计学分析。结果前驱糖尿病组118例，空腹血糖（6．48±0．52）mmol／L ，餐后2 h血糖（9．55±1．38）mmol／L ，糖化血红蛋白（5．83±0．22）％；糖尿病组145例，空腹血糖（13．81±2．12）mmol／L ，餐后2 h血糖（19．33 ± 3．79）mmol／L ，糖化血红蛋白（10．12 ± 0．45）％；均高于健康对照组（171例）的空腹血糖（5．31 ± 0．78）mmol／L ，餐后2 h血糖（6．05±1．12） mmol／L ，糖化血红蛋白（4．72 ± 0．51）％，差异均有统计学意义（P＜0．05）。糖化血红蛋白与空腹血糖和餐后2 h血糖均呈正相关（ P＜0．05）。糖化血红蛋白诊断糖尿病的敏感度和特异性为100．0％，诊断前驱糖尿病的敏感度为97．5％，特异性为100．0％。结论糖化血红蛋白能够有效区分前驱糖尿病和糖尿病，对于糖尿病的治疗监控具有重要意义。
목적：탐토당화혈홍단백검측재전구당뇨병진단화감측적림상의의。방법대434례성도군구궤관의원내분비과문진취진자진행공복혈당、찬후2h혈당화당화혈홍단백측정，병대기결과진행통계학분석。결과전구당뇨병조118례，공복혈당（6．48±0．52）mmol／L ，찬후2 h혈당（9．55±1．38）mmol／L ，당화혈홍단백（5．83±0．22）％；당뇨병조145례，공복혈당（13．81±2．12）mmol／L ，찬후2 h혈당（19．33 ± 3．79）mmol／L ，당화혈홍단백（10．12 ± 0．45）％；균고우건강대조조（171례）적공복혈당（5．31 ± 0．78）mmol／L ，찬후2 h혈당（6．05±1．12） mmol／L ，당화혈홍단백（4．72 ± 0．51）％，차이균유통계학의의（P＜0．05）。당화혈홍단백여공복혈당화찬후2 h혈당균정정상관（ P＜0．05）。당화혈홍단백진단당뇨병적민감도화특이성위100．0％，진단전구당뇨병적민감도위97．5％，특이성위100．0％。결론당화혈홍단백능구유효구분전구당뇨병화당뇨병，대우당뇨병적치료감공구유중요의의。
Objective To discuss the clinical significance of glycated hemoglobin in diagnosis and monitoring of pre‐diabetes mellitus(DM ) .Methods The fasting blood glucose ,2 h postprandial blood glucose and glycosylated he‐moglobin in 434 outpatients in the endocrinological clinic of the Institution Hospital of Chengdu Military Region were detected and the results were statistical analyzed .Results In the pre‐DM group(118 cases) ,the fasting blood glucose was(6 .48 ± 0 .52)mmol/L ,2 h postprandial blood glucose was(9 .55 ± 1 .38)mmol/L and glycosylated hemoglobin was(5 .83 ± 0 .22)% ;in the diabetes group(145 cases) ,the fasting blood glucose was(13 .81 ± 2 .12)mmol/L ,2 h postprandial blood glucose was(19 .33 ± 3 .79)mmol/L and glycosylated hemoglobin was(10 .12 ± 0 .45)% ;in the control group(171 cases) ,the fasting blood glucose was(5 .31 ± 0 .78)mmol/L ,2 h postprandial blood glucose was (6 .05 ± 1 .12) mmol/L and glycosylated hemoglobin was(4 .72 ± 0 .51)% ,the differences were statistically signifi‐cance(P<0 .05) .Glycosylated hemoglobin level was positively correlated with fast glucose and 2 h postprandial blood glucose (P<0 .05) .The sensitivity and specificity of glycated hemoglobin for diagnosing DM were 100 .0% and its sensitivity and specificity for diagnosing pre‐DM were 97 .5% and 100% respectively .Conclusion Glycated hemoglo‐bin can effectively differentiate diabetes from pre‐DM ,which has an important significance in the treatment and moni‐toring of DM .