国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
8期
1043-1044,1046
,共3页
降钙素原%老年人%肺部感染%受试者工作特征曲线
降鈣素原%老年人%肺部感染%受試者工作特徵麯線
강개소원%노년인%폐부감염%수시자공작특정곡선
procalcitonin%elderly%pulmonary infection%receiver operating characteristic curve
目的：探讨降钙素原（PCT）联合C反应蛋白（CRP）在老年患者肺部感染中的诊断价值。方法选取2013年3月至2014年3月泸州医学院附属医院收治的老年住院患者145例，按有无肺部感染及感染严重程度分为无感染组（43例）、局部感染组（68例）、重症感染组（34例），检测其血清PCT、全血CRP水平及白细胞（WBC）计数，并绘制受试者工作特征曲线（ROC曲线），比较各炎症指标对老年患者肺部细菌感染的诊断价值。结果重症感染组PC T水平明显高于局部感染组和无感染组，差异均有统计学意义（P＜0．05），PCT的ROC曲线下面积（AUC）为0．960 ± 0．033，CRP为 0．717 ± 0．084，WBC为0．582 ± 0．094。在PCT阈值为0．2μg／mL时，其诊断灵敏度为95．1％，特异度为88．4％，Youden指数为0．835；在CRP阈值为67．72 mg／L时，其灵敏度为57．8％，特异度为83．7％，Youden指数为0．415。WBC的AUC不具有诊断意义。结论 PCT是一个较为理想的诊断老年患者肺部细菌感染及判断感染严重程度的标志物，PCT联合CRP能更好地辅助诊断老年患者肺部感染。
目的：探討降鈣素原（PCT）聯閤C反應蛋白（CRP）在老年患者肺部感染中的診斷價值。方法選取2013年3月至2014年3月瀘州醫學院附屬醫院收治的老年住院患者145例，按有無肺部感染及感染嚴重程度分為無感染組（43例）、跼部感染組（68例）、重癥感染組（34例），檢測其血清PCT、全血CRP水平及白細胞（WBC）計數，併繪製受試者工作特徵麯線（ROC麯線），比較各炎癥指標對老年患者肺部細菌感染的診斷價值。結果重癥感染組PC T水平明顯高于跼部感染組和無感染組，差異均有統計學意義（P＜0．05），PCT的ROC麯線下麵積（AUC）為0．960 ± 0．033，CRP為 0．717 ± 0．084，WBC為0．582 ± 0．094。在PCT閾值為0．2μg／mL時，其診斷靈敏度為95．1％，特異度為88．4％，Youden指數為0．835；在CRP閾值為67．72 mg／L時，其靈敏度為57．8％，特異度為83．7％，Youden指數為0．415。WBC的AUC不具有診斷意義。結論 PCT是一箇較為理想的診斷老年患者肺部細菌感染及判斷感染嚴重程度的標誌物，PCT聯閤CRP能更好地輔助診斷老年患者肺部感染。
목적：탐토강개소원（PCT）연합C반응단백（CRP）재노년환자폐부감염중적진단개치。방법선취2013년3월지2014년3월로주의학원부속의원수치적노년주원환자145례，안유무폐부감염급감염엄중정도분위무감염조（43례）、국부감염조（68례）、중증감염조（34례），검측기혈청PCT、전혈CRP수평급백세포（WBC）계수，병회제수시자공작특정곡선（ROC곡선），비교각염증지표대노년환자폐부세균감염적진단개치。결과중증감염조PC T수평명현고우국부감염조화무감염조，차이균유통계학의의（P＜0．05），PCT적ROC곡선하면적（AUC）위0．960 ± 0．033，CRP위 0．717 ± 0．084，WBC위0．582 ± 0．094。재PCT역치위0．2μg／mL시，기진단령민도위95．1％，특이도위88．4％，Youden지수위0．835；재CRP역치위67．72 mg／L시，기령민도위57．8％，특이도위83．7％，Youden지수위0．415。WBC적AUC불구유진단의의。결론 PCT시일개교위이상적진단노년환자폐부세균감염급판단감염엄중정도적표지물，PCT연합CRP능경호지보조진단노년환자폐부감염。
Objective To investigate the diagnostic value of procalcitonin(PCT) combined with C‐reactive protein (CRP) in the pulmonary infection in elderly patients .Methods 145 cases of inpatients in Affiliated Hospital of Luzhou Medical College from Mar .2013 to Mar .2014 were selected and divided into three groups [non‐infection group (43 cases) ,local infection group (68 ca‐ses) ,severe infection group (34 cases)] according to whether they have pulmonary bacterial infection and the severity of infection . Serum PCT level ,blood CRP level and white blood cell (WBC) counts were detected ,and the receiver operating characteristic curve (ROC curve) were evaluated .The diagnostic values of these inflammatory markers were compared .Results The serum PCT level in the serve infection group was significantly higher than those in the local infection group and non‐infection group (P<0 .05) ,area under the ROC curve (AUC) of PCT was 0 .960 ± 0 .033 ,CRP was 0 .717 ± 0 .084 ,WBC was 0 .582 ± 0 .094 ,respectively .When the threshold of PCT was 0 .2 μg/mL ,the diagnostic sensitivity was 95 .1% ,specificity was 88 .4% ,Youden index was 0 .835 ;when the threshold of CRP was 67 .72 mg/L ,the diagnostic sensitivity was 57 .8% ,specificity was 83 .7% ,Youden index was 0 .415 .The AUC of WBC had no diagnostic value .Conclusion PCT could be an ideal marker in diagnosis of bacterial pneumonia and assessing the severity of infection in elderly patients .PCT combined with CRP ,WBC could provide better auxiliary diagnosis of the pulmonary infection in elderly patients .
