国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
8期
1036-1037,1040
,共3页
矮小症%激发试验%胰岛素样生长因子1%25-羟维生素D
矮小癥%激髮試驗%胰島素樣生長因子1%25-羥維生素D
왜소증%격발시험%이도소양생장인자1%25-간유생소D
dwarfism%stimulating test%insulin growth factor-1%25-hydroxyl vitamin D
目的:探讨生长激素(G H )激发试验对矮小症儿童的诊断价值及可能影响因素。方法对642例矮小症儿童进行精氨酸和左旋多巴联合GH激发试验,测定激发后30、60、90、120、150、180 min GH水平。将患儿分为GH缺乏症(GHD)组(GH峰值小于10 ng/mL)和非GHD组(GH峰值大于或等于10 ng/mL),比较两组患儿体格及实验室检测指标。结果共检出GHD患儿441例(68.69% ),非GHD患儿201例(31.31% ),两组患儿所占比例比较差异有统计学意义(χ2=6.19,P<0.05)。GH峰值出现时间以30、150 min相对较多,分别占22.42%和34.27%,峰值有延后现象。GHD组与非GHD组患儿年龄、身高标准差、体质量指数、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、胰岛素样生长因子1和25‐羟维生素D水平比较差异有统计学意义( P<0.05)。结论精氨酸和左旋多巴联合激发试验可作为矮小症儿童GH缺乏的诊断试验;GH水平与多种体格和实验室检测指标有关,诊断GHD需综合考虑相关影响因素。
目的:探討生長激素(G H )激髮試驗對矮小癥兒童的診斷價值及可能影響因素。方法對642例矮小癥兒童進行精氨痠和左鏇多巴聯閤GH激髮試驗,測定激髮後30、60、90、120、150、180 min GH水平。將患兒分為GH缺乏癥(GHD)組(GH峰值小于10 ng/mL)和非GHD組(GH峰值大于或等于10 ng/mL),比較兩組患兒體格及實驗室檢測指標。結果共檢齣GHD患兒441例(68.69% ),非GHD患兒201例(31.31% ),兩組患兒所佔比例比較差異有統計學意義(χ2=6.19,P<0.05)。GH峰值齣現時間以30、150 min相對較多,分彆佔22.42%和34.27%,峰值有延後現象。GHD組與非GHD組患兒年齡、身高標準差、體質量指數、丙氨痠氨基轉移酶、天鼕氨痠氨基轉移酶、胰島素樣生長因子1和25‐羥維生素D水平比較差異有統計學意義( P<0.05)。結論精氨痠和左鏇多巴聯閤激髮試驗可作為矮小癥兒童GH缺乏的診斷試驗;GH水平與多種體格和實驗室檢測指標有關,診斷GHD需綜閤攷慮相關影響因素。
목적:탐토생장격소(G H )격발시험대왜소증인동적진단개치급가능영향인소。방법대642례왜소증인동진행정안산화좌선다파연합GH격발시험,측정격발후30、60、90、120、150、180 min GH수평。장환인분위GH결핍증(GHD)조(GH봉치소우10 ng/mL)화비GHD조(GH봉치대우혹등우10 ng/mL),비교량조환인체격급실험실검측지표。결과공검출GHD환인441례(68.69% ),비GHD환인201례(31.31% ),량조환인소점비례비교차이유통계학의의(χ2=6.19,P<0.05)。GH봉치출현시간이30、150 min상대교다,분별점22.42%화34.27%,봉치유연후현상。GHD조여비GHD조환인년령、신고표준차、체질량지수、병안산안기전이매、천동안산안기전이매、이도소양생장인자1화25‐간유생소D수평비교차이유통계학의의( P<0.05)。결론정안산화좌선다파연합격발시험가작위왜소증인동GH결핍적진단시험;GH수평여다충체격화실험실검측지표유관,진단GHD수종합고필상관영향인소。
Objective To investigate the diagnostic value of growth hormone(GH) stimulating test in dwarfism of children and related influencing factors .Methods Arginine and L‐dopa were applied to perform GH stimulating test in 642 children with dwarf‐ism .GH levels were detected at 30 ,60 ,90 ,120 ,150 ,180 min after stimulation .All children were divided into GH deficiency (GHD) group ,with peak value of GH less than 10 ng/mL ,and non‐GHD group ,with peak value of GH at least 10 ng/mL .Physical and la‐boratory data of the two groups were compared .Results The proportion of children with GHD and without GHD were 68 .69%and 31 .31% ,respectively ,and with statistical difference(χ2 =6 .19 ,P<0 .05) .The GH peak value ,with a delay ,mainly appeared at 30 and 150 min after stimulation ,accounting for 22 .42% and 34 .27% .Levels of age ,body height standard deviation ,body mass in‐dex ,alanine aminotransferase ,aspartate aminotransferase ,insulin growth factor‐1 and 25‐hydroxyl vitamin D were statistically dif‐ferent between the two groups(P<0 .05) .Conclusion Arginine and L‐dopa combined stimulating test could be used for the diagno‐sis of GHD in children with dwarfism .GH level might be correlated with various physical and laboratory parameters ,which should be considered for the diagnosis of GHD .