CAJ | 학술논문

目的：探讨肿瘤性贫血患者外周血铁调素（Hepcidin）水平变化及其与白介素‐6（IL‐6）、血清铁（SI）水平变化的相关性，了解其在肿瘤性贫血中的作用，为临床治疗提供依据。方法：将肿瘤性贫血患者100例作为观察组，另选择同期来我院体检的人员20例作为对照组。采用酶联免疫法（ELISA）检测患者血清中 Hepcidin 、IL‐6，亚铁嗪终点比色法测定 SI 浓度，了解 Hepcidin 与贫血、IL‐6的相关性。结果：肿瘤性贫血患者外周血 Hepcidin 、IL‐6浓度均明显高于对照组（P ＜0．05），SI 浓度低于对照组（P＜0．05）。随着贫血程度加重，外周血 Hepcidin 、IL‐6浓度升高（P ＜0．05），SI 浓度降低（P ＜0．05）。肿瘤性贫血患者血清 Hepcidin 与 IL‐6成正相关（r ＝0．33，P ＜0．05），血清 Hepcidin 与 SI 水平呈负相关（r ＝－0．24，P ＜0．05），血清 IL‐6与 SI 水平呈负相关（r ＝－0．21，P＜0．05）。结论：肿瘤性贫血患者外周血中 Hepcidin 、IL‐6浓度明显升高，Hepcidin 与 IL‐6成正相关，Hepcidin 及 IL‐6在肿瘤性贫血发病中起重要作用，及早降低 Hepcidin 、IL‐6浓度，有助于阻止贫血的发展，为肿瘤性贫血的治疗提供新的策略。
목적：탐토종류성빈혈환자외주혈철조소（Hepcidin）수평변화급기여백개소‐6（IL‐6）、혈청철（SI）수평변화적상관성，료해기재종류성빈혈중적작용，위림상치료제공의거。방법：장종류성빈혈환자100례작위관찰조，령선택동기래아원체검적인원20례작위대조조。채용매련면역법（ELISA）검측환자혈청중 Hepcidin 、IL‐6，아철진종점비색법측정 SI 농도，료해 Hepcidin 여빈혈、IL‐6적상관성。결과：종류성빈혈환자외주혈 Hepcidin 、IL‐6농도균명현고우대조조（P ＜0．05），SI 농도저우대조조（P＜0．05）。수착빈혈정도가중，외주혈 Hepcidin 、IL‐6농도승고（P ＜0．05），SI 농도강저（P ＜0．05）。종류성빈혈환자혈청 Hepcidin 여 IL‐6성정상관（r ＝0．33，P ＜0．05），혈청 Hepcidin 여 SI 수평정부상관（r ＝－0．24，P ＜0．05），혈청 IL‐6여 SI 수평정부상관（r ＝－0．21，P＜0．05）。결론：종류성빈혈환자외주혈중 Hepcidin 、IL‐6농도명현승고，Hepcidin 여 IL‐6성정상관，Hepcidin 급 IL‐6재종류성빈혈발병중기중요작용，급조강저 Hepcidin 、IL‐6농도，유조우조지빈혈적발전，위종류성빈혈적치료제공신적책략。
Objective :To investigate the clinical significance of serum Hepcidin level and the relationships between Hepcidin level and IL‐6 ,Serum iron levels in patients with cancer‐related amemia (CAR) ,and provide ex‐perimental evidence for prevention and treatment of CAR .Methods :100 cases in our hospital from September 2012 to October 2014 patients with cancer‐related anemia were treated ,was set to the observation group ,and the other op‐tions over the same period 20 cases to the hospital medical staff ,served as controls .Serum Hepcidin and IL‐6 levels were assayed by enzyme‐linked immunosorbent assay(ELISA) ,Serum SI levels were assayer by ferrozine .Results :① The levels of serum Hepcidin and IL‐6 compared with the control group increased ,but the levels of serum SI de‐creased ,the difference was statistically significant (P< 0 .05) .② Along with the degree of anemia increased ,the level of Hepcidin and IL‐6 has been rised obviously ,but the level of SI has been reduced(P < 0 .05) .③ In patients with cancer‐related anemia ,Hepcidin level were positively correlated with IL‐6 level(P < 0 .05) ,and Hepcidin and IL‐6 levels were negative clrrelated with SI level(P < 0 .05) .Conclusion :The levels of serum Hepcidin and IL‐6 compared with the control group increased .Hepcidin level were positively correlated with IL‐6 level .The Hepcidin and IL‐6 plays an important role in the disease in CAR ,and reducing the level of NO as soon as possible ,is assist for prevent the progress of anemia .that will provide a new strategy of therapy for CAR .