CAJ | 학술논문

目的：了解该院肺炎链球菌的临床分布及监测其耐药变迁，为临床有效抗感染提供参考依据。方法用VITEK 2 Compact进行细菌鉴定和药敏数据分析，用WHONET5．3软件和SPSS13．0软件进行统计分析。结果2008～2013年共分离出588株肺炎链球菌，主要分布于重症监护病房（IC U ），其次为呼吸内科、普通儿科；主要来源于痰液标本，其次为咽拭子和血液标本。红霉素耐药率最高，其次为青霉素和复方磺胺甲噁唑；肺炎链球菌对左旋氧氟沙星、氧氟沙星、万古霉素、氯霉素、利奈唑烷仍然敏感。结论肺炎链球菌的耐药率不断上升，应重视细菌耐药性监测，根据药敏试验结果合理选用抗菌药物。
목적：료해해원폐염련구균적림상분포급감측기내약변천，위림상유효항감염제공삼고의거。방법용VITEK 2 Compact진행세균감정화약민수거분석，용WHONET5．3연건화SPSS13．0연건진행통계분석。결과2008～2013년공분리출588주폐염련구균，주요분포우중증감호병방（IC U ），기차위호흡내과、보통인과；주요래원우담액표본，기차위인식자화혈액표본。홍매소내약솔최고，기차위청매소화복방광알갑오서；폐염련구균대좌선양불사성、양불사성、만고매소、록매소、리내서완잉연민감。결론폐염련구균적내약솔불단상승，응중시세균내약성감측，근거약민시험결과합리선용항균약물。
Objective To understand the clinical distribution and monitoring the change of resistance of Streptococcus pneumoni‐ae ,effective for clinical anti infection to provide reference .Methods Using VITEK 2 Compact to analyze the bacteria identification and drug sensitivity data ,and using WHONET5 .3 software and SPSS13 .0 software for statistical analysis .Results From 2008 to 2013 ,588 strains of Streptococcus pneumoniae were isolated ,mainly distributed in the intensive care unit (ICU) ,followed by respir‐atory department of internal medicine ,general pediatrics ;mainly from sputum samples ,followed by the throat swabs and blood samples .The highest resistant rate was erythromycin ,followed by penicillin and cotrimoxazole ;Streptococcus pneumoniae remains sensitive to ofloxacin ,levofloxacin ,vancomycin ,linezolid ,chloramphenicol .Conclusion The resistance rate of Streptococcus pneu‐moniae was rising ,and that great attention should be paid to the bacterial drug resistance so as to reasonably use a antibiotics based on the result of drug susceptibility testing .