CAJ | 학술논문

目的：探讨缺氧诱导因子（HIF‐1α）在胆囊癌组织中的表达及其临床意义。方法：选取30例胆囊癌组织作为观察组，18例正常慢性胆囊炎组织作为对照组，对观察组和对照组分别利用免疫组织化学技术来检测石蜡病理切片组织中 HIF‐1α的表达情况，进一步分析 HIF‐1α与胆囊癌临床病理因素及预后之间的关系。结果：HIF‐1α蛋白在30例胆囊癌组织中的阳性表达率为63．3％（19／30），而在18例胆囊炎组织中均未见表达，两者间有极显著性差异（P＜0．01）。 HIF‐1α表达与肿瘤 TNM 分期（P＜0．05）及淋巴结转移以及肿瘤的大小呈正相关（P ＜0．05），而与胆囊癌组织分化程度、患者的年龄和性别等无关（P ＞0．05），与预后呈负相关（（35．0％ vs 16．7％，P ＜0． 05）。结论：HIF‐1α的在胆囊癌的发生发展过程中起着重要作用，可作为判断胆囊癌诊断及预后的有用指标。
목적：탐토결양유도인자（HIF‐1α）재담낭암조직중적표체급기림상의의。방법：선취30례담낭암조직작위관찰조，18례정상만성담낭염조직작위대조조，대관찰조화대조조분별이용면역조직화학기술래검측석사병리절편조직중 HIF‐1α적표체정황，진일보분석 HIF‐1α여담낭암림상병리인소급예후지간적관계。결과：HIF‐1α단백재30례담낭암조직중적양성표체솔위63．3％（19／30），이재18례담낭염조직중균미견표체，량자간유겁현저성차이（P＜0．01）。 HIF‐1α표체여종류 TNM 분기（P＜0．05）급림파결전이이급종류적대소정정상관（P ＜0．05），이여담낭암조직분화정도、환자적년령화성별등무관（P ＞0．05），여예후정부상관（（35．0％ vs 16．7％，P ＜0． 05）。 결론：HIF‐1α적재담낭암적발생발전과정중기착중요작용，가작위판단담낭암진단급예후적유용지표。
Objective :To detect the expression of HIF‐1α(hypoxia inducible factor lα) in the tissue of gall‐bladder carcinoma and to evaluate its clinical significance .Methods :HIF‐1α was examined in 30 patients of primary gallbladder carcinoma and in 18 patients suffering cholecystitis respectively using Immunohistochemistry technology , and then analyze the relationship between clinico‐phathological factor of gallbladder carcinoma and the expression of HIF‐1 .Results :The positive rate of HIF‐1 in gallbladder carcinomas was 63 .3% (19/30) .In 18 cases of cholecysti‐tis ,no HIF‐1αexpression was detected .The positive rate of HIF‐1 in gallbladder carcinomas was significantly higher than that in the tissues of cholecystitis (P < 0 .01) .HIF‐1 protein expression was closely relevant with lymphatic metastasis(P = 0 .043) ,TNM stage(P = 0 .021)and tumor size(P = 0 .028) while was negative correlations with prognosis((35 .0% vs 16 .7% ,P= 0 .037) ,but uncorrelated with the pathological grading ,the age and sex of patients (P> 0 .05) .Conclusion :High expression of HIF‐1 plays a considerable role in development of gallbladder carcino‐ma .HIF‐1 could possibly become a helpful marker for diagnosing and assessing prognosis in the carcinoma of gall‐bladder .