CAJ | 학술논문

目的：检测胰岛素抵抗2型糖尿病（T2DM ）患者血清脂联素与炎症因子的水平并分析其相关性。方法选择胰岛素抵抗指数（HOMA‐IR）高于2．69的 T2DM 患者（T2DM 组）和 HOMA‐IR为1．00的健康人（CON组）作为研究对象，检测并比较两组研究对象间血清脂联素、超敏C反应蛋白（hs‐CRP）、肿瘤坏死因子‐α（T N F‐α）、白细胞介素‐1β（IL‐1β）、白细胞介素‐6（IL‐6）、白细胞介素‐8（IL‐8）、白细胞介素‐10（IL‐10）和白细胞介素‐18（IL‐18）的差异，分析T2DM患者血清脂联素与炎症因子的相关性。结果 T2DM 患者hs‐CRP、TNF‐α、IL‐1β、IL‐6、IL‐8和IL‐18水平均显著高于CON组，而脂联素和IL‐10水平显著低于CON组，差异均有统计学意义（P＜0．05）。将TDM组患者血清脂联素和hs‐CRP、TNF‐α、IL‐1β、IL‐6、IL‐8、IL‐10和IL‐18进行相关性分析，表明血清脂联素和hs‐CRP、TNF‐α、IL‐1β、IL‐6、IL‐8和IL‐18均呈负相关（rs ＜0，P＜0．05），与IL‐10呈正相关（rs ＞0，P＜0．05）。结论胰岛素抵抗T2DM患者处于炎症紊乱状态，血清脂联素显著低于健康人，其水平与炎症因子密切相关。
목적：검측이도소저항2형당뇨병（T2DM ）환자혈청지련소여염증인자적수평병분석기상관성。방법선택이도소저항지수（HOMA‐IR）고우2．69적 T2DM 환자（T2DM 조）화 HOMA‐IR위1．00적건강인（CON조）작위연구대상，검측병비교량조연구대상간혈청지련소、초민C반응단백（hs‐CRP）、종류배사인자‐α（T N F‐α）、백세포개소‐1β（IL‐1β）、백세포개소‐6（IL‐6）、백세포개소‐8（IL‐8）、백세포개소‐10（IL‐10）화백세포개소‐18（IL‐18）적차이，분석T2DM환자혈청지련소여염증인자적상관성。결과 T2DM 환자hs‐CRP、TNF‐α、IL‐1β、IL‐6、IL‐8화IL‐18수평균현저고우CON조，이지련소화IL‐10수평현저저우CON조，차이균유통계학의의（P＜0．05）。장TDM조환자혈청지련소화hs‐CRP、TNF‐α、IL‐1β、IL‐6、IL‐8、IL‐10화IL‐18진행상관성분석，표명혈청지련소화hs‐CRP、TNF‐α、IL‐1β、IL‐6、IL‐8화IL‐18균정부상관（rs ＜0，P＜0．05），여IL‐10정정상관（rs ＞0，P＜0．05）。결론이도소저항T2DM환자처우염증문란상태，혈청지련소현저저우건강인，기수평여염증인자밀절상관。
Objective To examine the serum levels of adiponectin and inflammatory factors in type 2 diabetes mellitus (T2DM ) patients with insulin resistance and to analyze their correlation .Methods T2DM patients (T2DM group) with insulin resistance and HOMA‐IR> 2 .69 and healthy persons (CON group) of HOMA‐IA=1 .0 were selected as the research subjects .The serum levels of adiponectin and inflammatory factors (hs‐CRP ,TNF‐α,IL‐1β, IL‐6 ,IL‐8 ,IL‐10 and IL‐18) were examined and compared between the two groups .Results The levels of hs‐CRP , TNF‐α,IL‐1β,IL‐6 ,IL‐8 and IL‐18 in the T2DM group were significantly higher those in the CON group (P<0 .05) ,while the levels of adiponectin and IL‐10 were lower than those in the CON group ,the differeces were statis‐tially significant (P<0 .05) .The adiponectin in T2DM group was negatively correlated with hs‐CRP ,TNF‐α,IL‐1β, IL‐6 ,IL‐8 and IL‐18 (rs<0 ,P<0 .05) ,but positively correlated with IL‐10 (rs >0 ,P<0 .05) .Conclusion T2DM patients with insulin resistance are in the inflammation disorder state and the adiponectin level is significantly lower than that in the healthy people .The adiponectin level is closely correlated with the inflammatory factors .