CAJ | 학술논문

目的：观察补阳还五汤对脑卒中后抑郁大鼠行为学的影响。方法选择雄性SD大鼠，根据旷场试验基线值，选择评分相近的60只大鼠随机分为假手术组、卒中组、PSD组、补阳还五汤组、氟西汀组，共5组，每组12只。采用大脑中动脉线栓法建立永久性局灶性脑缺血模型结合CUMS及孤养的方法复制PSD模型。通过体重测量、神经功能评分、糖水消耗实验、旷场实验等指标观察各组大鼠行为学变化。结果与假手术组、卒中组比较， PSD组大鼠体重和糖水消耗量降低、旷场实验自发活动下降、神经功能缺损加重（ P＜0．05或P＜0．01）；与PSD组比较，补阳还五汤组和氟西汀组均能增加大鼠体重、糖水消耗量及自发行为，改善其神经功能缺损（ P＜0．05或P＜0．01）。结论 PSD大鼠出现行为学异常，补阳还五汤可以明显改善其行为学症状，具有一定抗抑郁作用，其疗效与氟西汀相当。
목적：관찰보양환오탕대뇌졸중후억욱대서행위학적영향。방법선택웅성SD대서，근거광장시험기선치，선택평분상근적60지대서수궤분위가수술조、졸중조、PSD조、보양환오탕조、불서정조，공5조，매조12지。채용대뇌중동맥선전법건립영구성국조성뇌결혈모형결합CUMS급고양적방법복제PSD모형。통과체중측량、신경공능평분、당수소모실험、광장실험등지표관찰각조대서행위학변화。결과여가수술조、졸중조비교， PSD조대서체중화당수소모량강저、광장실험자발활동하강、신경공능결손가중（ P＜0．05혹P＜0．01）；여PSD조비교，보양환오탕조화불서정조균능증가대서체중、당수소모량급자발행위，개선기신경공능결손（ P＜0．05혹P＜0．01）。결론 PSD대서출현행위학이상，보양환오탕가이명현개선기행위학증상，구유일정항억욱작용，기료효여불서정상당。
Objective To observe the effect of a traditional Chinese medicine, BuyangHuanwu Decoction, on the ethology in rat models of post-stroke depression ( PSD) .Methods Sixty male SD rats, after open-field ethology scoring, were randomly divided into five groups ( 12 rats in each group):sham operation group, cerebral ischemic stroke group, post-stroke depression ( PSD) group, BuyangHuanwu Decoction group, and fluoxetine group.The rat PSD models were established with separately breeding and chronic unpredictable moderate stress ( CUMS ) after middle cerebral artery occlusion. Behavior changes of the rats were detected by body weight measurement, neurological scoring, sugar consumption test and open-field test.Results Compared with the sham operation group and cerebral ischemic stroke group, the body weight,sugar consumption and open-field spontaneous activity in the PSD model group were decreased, and the neurological function deficits became more severe ( P <0.01 or P <0.05 ) .Compared with the PSD group, Both BuyangHuanwu Decoction group and fluoxetine group got significantly higher scores of body weight,sugar consumption and spontaneous activity,and improved neurological function deficits(P<0.01 or P<0.05).Conclusions PSD rats exhibit abnormal behavior.BuyangHuanwu Decoction can significantly improve the behavioral impairment of PSD rats. The antidepressant effect of BuyangHuanwu Decoction is comparable to that of fluoxetine in the treatment of PSD rats.