国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
5期
336-341
,共6页
慢性阻塞性肺疾病%群体结构%meta分析
慢性阻塞性肺疾病%群體結構%meta分析
만성조새성폐질병%군체결구%meta분석
Chronic obstructive pulmonary disease%Population structure%Meta analysis
目的 探讨COPD易感基因多态在不同地域的潜在差异关联.方法 对报道过的两个COPD相关的基因多态TNF-α-308G/A和EPHX1 His139/Arg进行地域分层的meta分析及群体结构分析.结果 发现EPHX1 His139/Arg并未显示出与COPD关联,而TNF-α-308G/A在亚洲人群中展示出了比较强的关联.结论 研究结果表明种族地域对COPD遗传易感性的研究有重要作用.
目的 探討COPD易感基因多態在不同地域的潛在差異關聯.方法 對報道過的兩箇COPD相關的基因多態TNF-α-308G/A和EPHX1 His139/Arg進行地域分層的meta分析及群體結構分析.結果 髮現EPHX1 His139/Arg併未顯示齣與COPD關聯,而TNF-α-308G/A在亞洲人群中展示齣瞭比較彊的關聯.結論 研究結果錶明種族地域對COPD遺傳易感性的研究有重要作用.
목적 탐토COPD역감기인다태재불동지역적잠재차이관련.방법 대보도과적량개COPD상관적기인다태TNF-α-308G/A화EPHX1 His139/Arg진행지역분층적meta분석급군체결구분석.결과 발현EPHX1 His139/Arg병미현시출여COPD관련,이TNF-α-308G/A재아주인군중전시출료비교강적관련.결론 연구결과표명충족지역대COPD유전역감성적연구유중요작용.
Objective To explore the potential different association between genes polymorphisms and chronic obstructive pulmonary disease (COPD) phenotype in different geographic regions.Methods The population stratification meta-analysis and population structure analysis based on two COPD-related gene polymorphisms TNF-α-308G/A and EPHX1 His139/Arg were performed.Results The results showed that EPHX1 His139/Arg is not associated with COPD whereas TNF-α-308G/A is obviously associated with COPD in Asia population.Conclusions The results demonstrate the importance of ethnicity and geographic regions in identifying specific COPD susceptibility genes.
